PMID- 24588227
OWN - NLM
STAT- MEDLINE
DCOM- 20140421
LR  - 20140304
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 77
IP  - 5
DP  - 2014
TI  - Particles influence allergic responses in mice--role of gender and particle size.
PG  - 281-92
LID - 10.1080/15287394.2013.863746 [doi]
AB  - Epidemiological evidence suggesting that exposure to traffic air pollution may 
      enhance sensitization to common allergens in children is increasing, and animal 
      studies support biological plausibility and causality. The effect of air 
      pollution on respiratory symptoms was suggested to be gender dependent. Previous 
      studies showed that allergy-promoting activity of polystyrene particles (PSP) 
      increased with decreasing particle size after footpad injection of mice. The 
      primary aim of this study was to confirm the influence of particle size on the 
      immunoglobulin E (IgE)-promoting capacity of particles in an airway allergy 
      model. A second aim was to examine whether the allergy-promoting capacity of 
      particles was influenced by gender. Female and male mice were intranasally 
      exposed to the allergen ovalbumin (OVA) with or without ultrafine, fine, or 
      coarse PSP modeling the core of ambient air particles. After intranasal booster 
      immunizations with OVA, serum levels of OVA-specific IgE antibodies, and also 
      markers of airway inflammation and cellular responses in the lung-draining 
      mediastinal lymph nodes (MLN), were determined. PSP of all sizes promoted 
      allergic responses, measured as increased serum concentrations of OVA-specific 
      IgE antibodies. Further, PSP produced eosinophilic airway inflammation and 
      elevated MLN cell numbers as well as numerically reducing the percentage of 
      regulatory T cells. Ultrafine PSP produced stronger allergic responses to OVA 
      than fine and coarse PSP. Although PSP enhanced sensitization in both female and 
      male mice, significantly higher IgE levels and numbers of eosinophils were 
      observed in females than males. However, the allergy-promoting effect of PSP was 
      apparently independent of gender. Thus, our data support the notion that ambient 
      air particle pollution may affect development of allergy in both female and male 
      individuals.
FAU - Alberg, Torunn
AU  - Alberg T
AD  - a Division of Environmental Medicine , Norwegian Institute of Public Health , 
      Oslo , Norway.
FAU - Hansen, Jitka Stilund
AU  - Hansen JS
FAU - Lovik, Martinus
AU  - Lovik M
FAU - Nygaard, Unni Cecilie
AU  - Nygaard UC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 0 (Particulate Matter)
RN  - 0 (Polystyrenes)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Hypersensitivity/*pathology
MH  - Immunoglobulin E/blood
MH  - Inflammation/chemically induced/pathology
MH  - Lymph Nodes/cytology
MH  - Male
MH  - Mice
MH  - Ovalbumin/*adverse effects
MH  - Particle Size
MH  - Particulate Matter/*adverse effects
MH  - Polystyrenes/*adverse effects
MH  - Respiratory Hypersensitivity/*chemically induced
MH  - Sex Factors
MH  - T-Lymphocytes, Helper-Inducer
MH  - T-Lymphocytes, Regulatory
EDAT- 2014/03/05 06:00
MHDA- 2014/04/22 06:00
CRDT- 2014/03/05 06:00
PHST- 2014/03/05 06:00 [entrez]
PHST- 2014/03/05 06:00 [pubmed]
PHST- 2014/04/22 06:00 [medline]
AID - 10.1080/15287394.2013.863746 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 2014;77(5):281-92. doi: 10.1080/15287394.2013.863746.