PMID- 24588622
OWN - NLM
STAT- MEDLINE
DCOM- 20150416
LR  - 20191210
IS  - 1939-165X (Electronic)
IS  - 0275-6382 (Linking)
VI  - 43
IP  - 2
DP  - 2014 Jun
TI  - Analytical performance of a dry chemistry analyzer designed for in-clinic use.
PG  - 206-17
LID - 10.1111/vcp.12122 [doi]
AB  - BACKGROUND: The Heska Dri-Chem 4000 uses dry slide technology to evaluate serum 
      or plasma. No previous independent performance evaluation is published to the 
      authors' knowledge. OBJECTIVES: The objectives were to (1) characterize 
      analytical performance of a Dri-Chem 4000 by measuring precision and bias, (2) 
      compare analytical performance of that Dri-Chem 4000 unit with a predetermined 
      quality requirement, and (3) determine whether statistical QC of the Dri-Chem 
      4000 is possible using the 13s control rule. METHODS: Sixteen analytes were 
      measured using plasma from dogs, cats, and horses. Coefficient of variation (CV), 
      bias, and observed total error (TEobs ) were calculated. TEobs was compared with 
      allowable total error (TEa ). Sigma metric and quality goal index were calculated 
      where relevant. QC validation was performed. RESULTS: Bias and TEobs calculated 
      using quality control material (QCM) data were smaller than those calculated 
      using method comparison data. Using TEobs calculated from species-specific CV and 
      QCM-based bias, 100% of analytes in each species met ASVCP-recommended TEa . 
      Desired error detection and false rejection rates were achievable using the 13s 
      control rule and ASVCP-recommended TEa values for 9/16 (56%) of analytes in dogs, 
      9/14 (64%) of analytes in cats, and 8/13 (62%) of analytes in horses. 
      CONCLUSIONS: Analytical performance of the Dri-Chem 4000 is comparable to that 
      reported by other authors for other small benchtop biochemistry analyzers. 
      Statistical QC using a simple control rule is possible for most analytes in dogs, 
      cats, and horses.
CI  - (c) 2014 American Society for Veterinary Clinical Pathology and European Society 
      for Veterinary Clinical Pathology.
FAU - Flatland, Bente
AU  - Flatland B
AD  - Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, 
      University of Tennessee, Knoxville, TN, USA.
FAU - Breickner, Liesl C
AU  - Breickner LC
FAU - Fry, Michael M
AU  - Fry MM
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20140303
PL  - United States
TA  - Vet Clin Pathol
JT  - Veterinary clinical pathology
JID - 9880575
SB  - IM
MH  - Animals
MH  - Blood Chemical Analysis/instrumentation/standards/*veterinary
MH  - Cats
MH  - Diagnostic Errors/*veterinary
MH  - Dogs
MH  - Horses
MH  - Point-of-Care Systems/standards
MH  - Quality Control
MH  - Reproducibility of Results
MH  - Species Specificity
OTO - NOTNLM
OT  - Canine
OT  - dry chemistry
OT  - equine
OT  - feline
OT  - method comparison
OT  - point-of-care
EDAT- 2014/03/05 06:00
MHDA- 2015/04/17 06:00
CRDT- 2014/03/05 06:00
PHST- 2014/03/05 06:00 [entrez]
PHST- 2014/03/05 06:00 [pubmed]
PHST- 2015/04/17 06:00 [medline]
AID - 10.1111/vcp.12122 [doi]
PST - ppublish
SO  - Vet Clin Pathol. 2014 Jun;43(2):206-17. doi: 10.1111/vcp.12122. Epub 2014 Mar 3.