PMID- 24589844
OWN - NLM
STAT- MEDLINE
DCOM- 20141114
LR  - 20211021
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 6
IP  - 2
DP  - 2014 Feb
TI  - Hypothalamic-mediated control of glucose balance in the presence and absence of 
      insulin.
PG  - 92-7
AB  - Diabetes afflicts hundreds of millions worldwide. People affected by type 1 
      diabetes mellitus (T1DM; the insulin-deficient form of diabetes) or type 2 
      diabetes mellitus (T2DM; the insulin-resistant form of diabetes) have 
      significantly reduced life expectancy compared to normal individuals. This is due 
      in part to the fact that (despite improvements) current anti-diabetic approaches 
      are suboptimal. Indeed, severe morbidities (e.g.: cardiovascular disease, 
      hypertension) are still too often associated with diabetes. Recent preclinical 
      results indicate that different types of hypothalamic neurons are endowed with 
      the ability to mediate the hyperglycemia-lowering action of the adipocyte-derived 
      hormone leptin in an insulin-dependent and insulin-independent fashion. These 
      results may pave the way for better anti-diabetic approaches and therefore 
      positively impact on life expectancy of diabetic subjects.
FAU - Fujikawa, Teppei
AU  - Fujikawa T
AD  - Department of Internal Medicine, Division of Hypothalamic Research, The 
      University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
FAU - Coppari, Roberto
AU  - Coppari R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (Insulin)
RN  - 0 (Leptin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Diabetes Mellitus/therapy
MH  - Glucose/*metabolism
MH  - Humans
MH  - Hypothalamus/*physiology
MH  - Insulin/*physiology
MH  - Leptin/*physiology
PMC - PMC3969278
EDAT- 2014/03/05 06:00
MHDA- 2014/11/15 06:00
PMCR- 2014/02/01
CRDT- 2014/03/05 06:00
PHST- 2014/03/05 06:00 [entrez]
PHST- 2014/03/05 06:00 [pubmed]
PHST- 2014/11/15 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - 100641 [pii]
AID - 10.18632/aging.100641 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2014 Feb;6(2):92-7. doi: 10.18632/aging.100641.