PMID- 24590453
OWN - NLM
STAT- MEDLINE
DCOM- 20140515
LR  - 20220321
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 134
IP  - 8
DP  - 2014 Apr 15
TI  - The population impact of familial cancer, a major cause of cancer.
PG  - 1899-906
LID - 10.1002/ijc.28510 [doi]
AB  - The population attributable fraction (PAF) defines the proportion of a disease 
      that would be prevented if the exposure to a particular risk factor was avoided. 
      Familial risk is a known risk factor for many cancers, but an unbiased estimation 
      of the PAF for familial risk requires a large study population to include rare 
      cancers. PAFs and their corresponding standardized incidence ratios (SIRs) were 
      calculated for familial relative risk among first-degree relatives (FDRs) and 
      second-degree relatives (SDRs) diagnosed with the same (concordant) invasive or 
      in situ cancers. Calculations were based on the Swedish Family-Cancer Database 
      considering 8,148,737 individuals. To assess environmental effects, PAFs were 
      also calculated for concordant cancers among spouses. Almost all cancers showed a 
      significant familial risk. The highest PAFs were found for the common cancers of 
      the prostate (13.94%), breast (7.46%) and colorectum (6.78%) among the FDRs. In 
      the FDRs, the overall PAF for any concordant cancer was 4.20%, but in the SDRs, 
      it was only 0.34%. The overall PAFs for in situ cancers were 0.86% and 0.56% for 
      the FDRs and SDRs, respectively. The overall independent familial PAF was 5.96% 
      for the invasive and in situ cancers in the FDRs and SDRs. The cancers between 
      spouses yielded an overall PAF of 0.14%. For esophageal cancer, the risk among 
      spouses was higher than the familial risk. Our study shows that the overall 
      familial PAF of 5.96%, although underestimated for sex-specific cancers, ranks as 
      the third most common population burden after tobacco smoking and unhealthy diet.
CI  - (c) 2013 UICC.
FAU - Frank, Christoph
AU  - Frank C
AD  - Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 
      Im Neuenheimer Feld 580, Heidelberg, Germany.
FAU - Fallah, Mahdi
AU  - Fallah M
FAU - Ji, Jianguang
AU  - Ji J
FAU - Sundquist, Jan
AU  - Sundquist J
FAU - Hemminki, Kari
AU  - Hemminki K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131031
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
SB  - IM
MH  - Breast Neoplasms/*epidemiology
MH  - Carcinoma in Situ/epidemiology
MH  - Colorectal Neoplasms/*epidemiology
MH  - Esophageal Neoplasms/epidemiology
MH  - *Family
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Prostatic Neoplasms/*epidemiology
MH  - Risk
MH  - Risk Factors
OTO - NOTNLM
OT  - Sweden
OT  - familial risk
OT  - population attributable fraction
OT  - spouse risk
OT  - standardized incidence ratio
EDAT- 2014/03/05 06:00
MHDA- 2014/05/16 06:00
CRDT- 2014/03/05 06:00
PHST- 2013/07/19 00:00 [received]
PHST- 2013/09/16 00:00 [accepted]
PHST- 2014/03/05 06:00 [entrez]
PHST- 2014/03/05 06:00 [pubmed]
PHST- 2014/05/16 06:00 [medline]
AID - 10.1002/ijc.28510 [doi]
PST - ppublish
SO  - Int J Cancer. 2014 Apr 15;134(8):1899-906. doi: 10.1002/ijc.28510. Epub 2013 Oct 
      31.