PMID- 24591527
OWN - NLM
STAT- MEDLINE
DCOM- 20160930
LR  - 20181202
IS  - 1752-8976 (Electronic)
IS  - 1470-3203 (Linking)
VI  - 16
IP  - 4
DP  - 2015 Dec
TI  - Effects of telmisartan on lipid metabolisms and proinflammatory factors secretion 
      of differentiated 3T3-L1 adipocytes.
PG  - 1061-8
LID - 10.1177/1470320313518252 [doi]
AB  - AIM: To investigate the effect of telmisartan on the lipometabolisms and the 
      proinflammatory factors secreted from 3T3-L1 adipocytes and to explore the 
      possible mechanisms. MATERIALS AND METHODS: Telmisartan was applied to interfere 
      with mature 3T3-L1 adipocytes. The culture's free fatty acids, interleukin 6 
      (IL-6) and tumor necrosis factor alpha (TNFalpha) were evaluated. Oil Red O staining was 
      used to determine the adipogenesis of 3T3-L1 adipocytes. (18)F-FDG uptake levels 
      corrected for protein content were determined by cellular radioactivity. The 
      total RNA was isolated for hybridization experimentation in the microarray. 
      RESULTS: Telmisartan reduced lipid storage and increased (18)F-FDG uptake in a 
      dose-dependent manner, reduced the levels of IL-6 and TNFalpha and increased those of 
      free fatty acids. One hundred and fifty-seven differentially expressed genes were 
      found by microarray. The mitogen-activated protein kinase (MAPK) signaling 
      pathway involved in the secretion of proinflammatory factor and lipid metabolisms 
      was affected by telmisartan. The expression of endothelial nitric oxide 
      synthetase gene 3 (Nos3) and carnitine palmitoyl transferase 1alpha (CPT1alpha) was 
      up-regulated by telmisartan. CONCLUSIONS: Telmisartan affected lipometabolisms 
      and the proinflammatory factors secreted from adipocytes. Nos3, CPT1alpha and the 
      MAPK pathway being affected by telmisartan may be the underlying cause of the 
      improvement in lipid metabolisms and secretion of proinflammatory factors of 
      differentiated 3T3-L1 adipocytes.
CI  - (c) The Author(s) 2014.
FAU - Kang, Chen
AU  - Kang C
AD  - Department of Endocrinology, PLA General Hospital, Beijing, China.
FAU - Yijun, Li
AU  - Yijun L
AD  - Department of Endocrinology, PLA General Hospital, Beijing, China.
FAU - Jingtao, Dou
AU  - Jingtao D
AD  - Department of Endocrinology, PLA General Hospital, Beijing, China 
      jingtaodou@sohu.com.
FAU - Changyu, Pan
AU  - Changyu P
AD  - Department of Endocrinology, PLA General Hospital, Beijing, China.
FAU - Wenhua, Yan
AU  - Wenhua Y
AD  - Department of Endocrinology, PLA General Hospital, Beijing, China.
FAU - Baoan, Wang
AU  - Baoan W
AD  - Department of Endocrinology, PLA General Hospital, Beijing, China.
FAU - Fangling, Ma
AU  - Fangling M
AD  - Department of Endocrinology, PLA General Hospital, Beijing, China.
FAU - Xianling, Wang
AU  - Xianling W
AD  - Department of Endocrinology, PLA General Hospital, Beijing, China.
FAU - Guoqing, Yang
AU  - Guoqing Y
AD  - Department of Endocrinology, PLA General Hospital, Beijing, China.
FAU - Yiming, Mu
AU  - Yiming M
AD  - Department of Endocrinology, PLA General Hospital, Beijing, China.
FAU - Juming, Lu
AU  - Juming L
AD  - Department of Endocrinology, PLA General Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140303
PL  - England
TA  - J Renin Angiotensin Aldosterone Syst
JT  - Journal of the renin-angiotensin-aldosterone system : JRAAS
JID - 100971636
RN  - 0 (Benzimidazoles)
RN  - 0 (Benzoates)
RN  - 0 (Inflammation Mediators)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - U5SYW473RQ (Telmisartan)
SB  - IM
MH  - 3T3-L1 Cells
MH  - Adipocytes/drug effects/*metabolism
MH  - Animals
MH  - Benzimidazoles/*pharmacology
MH  - Benzoates/*pharmacology
MH  - Biological Transport/drug effects
MH  - Cell Differentiation/*drug effects/genetics
MH  - Fluorodeoxyglucose F18/metabolism
MH  - Inflammation Mediators/*metabolism
MH  - Lipid Droplets/metabolism
MH  - Lipid Metabolism/*drug effects/genetics
MH  - MAP Kinase Signaling System/drug effects/genetics
MH  - Mice
MH  - Oligonucleotide Array Sequence Analysis
MH  - Real-Time Polymerase Chain Reaction
MH  - Telmisartan
OTO - NOTNLM
OT  - Angiotensin 11 receptor antagonist
OT  - adipocyte
OT  - microarray
OT  - proinflammatory factor
OT  - telmisartan
EDAT- 2014/03/05 06:00
MHDA- 2016/10/01 06:00
CRDT- 2014/03/05 06:00
PHST- 2014/03/05 06:00 [entrez]
PHST- 2014/03/05 06:00 [pubmed]
PHST- 2016/10/01 06:00 [medline]
AID - 1470320313518252 [pii]
AID - 10.1177/1470320313518252 [doi]
PST - ppublish
SO  - J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):1061-8. doi: 
      10.1177/1470320313518252. Epub 2014 Mar 3.