PMID- 24591551
OWN - NLM
STAT- MEDLINE
DCOM- 20140610
LR  - 20220409
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 170
IP  - 5
DP  - 2014 May
TI  - Influence of a positive family history of both type 2 diabetes and PCOS on 
      metabolic and endocrine parameters in a large cohort of PCOS women.
PG  - 727-39
LID - 10.1530/EJE-13-1035 [doi]
AB  - OBJECTIVE: There is evidence suggesting a strong genetic background of polycystic 
      ovary syndrome (PCOS). We aim to study the metabolic and endocrine 
      characteristics of PCOS women with and without a family history (FHx) of type 2 
      diabetes mellitus (T2DM) and PCOS. DESIGN: Cross-sectional study. METHODS: We 
      analysed the association of T2DM FHx and PCOS FHx with metabolic and endocrine 
      parameters in 714 PCOS women. RESULTS: A positive FHx of T2DM and PCOS were 
      prevalent in 36.8 and 21.4% of PCOS women respectively. We found an independent 
      association of T2DM FHx with central fat accumulation, obesity, prediabetes, 
      metabolic syndrome (MS), insulin resistance, low HDL and elevated blood pressure 
      (P<0.05 for all). PCOS FHx was independently associated with prediabetes 
      (P<0.05). We observed an independent association of PCOS FHx with clinical and 
      biochemical hyperandrogenism (P<0.05 for all), whereas there was no independent 
      association of T2DM FHx with hyperandrogenism. PCOS women with a positive FHx of 
      both T2DM and PCOS had an adverse metabolic and endocrine profile including a 
      linear increase in risk of obesity, central fat accumulation, MS, prediabetes and 
      low HDL (P<0.05 for all). CONCLUSIONS: Our findings suggest that the assessment 
      of FHx might allow risk stratification of PCOS women, which is important 
      considering the high prevalence of PCOS.
FAU - Lerchbaum, Elisabeth
AU  - Lerchbaum E
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Medical University of Graz, 8036 Graz, Austria.
FAU - Schwetz, Verena
AU  - Schwetz V
FAU - Giuliani, Albrecht
AU  - Giuliani A
FAU - Obermayer-Pietsch, Barbara
AU  - Obermayer-Pietsch B
LA  - eng
PT  - Journal Article
DEP - 20140410
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
SB  - IM
MH  - Abdominal Fat/pathology
MH  - Adiposity
MH  - Adult
MH  - Austria/epidemiology
MH  - Body Mass Index
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology/physiopathology
MH  - Dyslipidemias/epidemiology/physiopathology
MH  - *Family Health
MH  - Female
MH  - Humans
MH  - Hyperandrogenism/epidemiology/physiopathology
MH  - Hypertension/epidemiology/physiopathology
MH  - Insulin Resistance
MH  - Metabolic Syndrome/epidemiology/physiopathology
MH  - Obesity/epidemiology/physiopathology
MH  - Polycystic Ovary Syndrome/blood/*epidemiology/etiology/pathology
MH  - Prediabetic State/epidemiology/physiopathology
MH  - Risk Factors
EDAT- 2014/03/05 06:00
MHDA- 2014/06/11 06:00
CRDT- 2014/03/05 06:00
PHST- 2014/03/05 06:00 [entrez]
PHST- 2014/03/05 06:00 [pubmed]
PHST- 2014/06/11 06:00 [medline]
AID - EJE-13-1035 [pii]
AID - 10.1530/EJE-13-1035 [doi]
PST - epublish
SO  - Eur J Endocrinol. 2014 Apr 10;170(5):727-39. doi: 10.1530/EJE-13-1035. Print 2014 
      May.