PMID- 24592264
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20220317
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 5
DP  - 2014
TI  - Classical and Paradoxical Effects of TNF-alpha on Bone Homeostasis.
PG  - 48
LID - 10.3389/fimmu.2014.00048 [doi]
LID - 48
AB  - Tumor necrosis factor-alpha (TNF-alpha) plays an essential role in the regulation of bone 
      homeostasis in several chronic immune and inflammatory joint diseases, where 
      inhibition of TNF has led to significant clinical improvement. However, 
      TNF-activated pathways and mechanisms involved in bone remodeling remain unclear. 
      So far, TNF-alpha was known as an inhibitor of osteoblast differentiation and an 
      activator of osteoclastogenesis. Recent contradictory findings indicated that 
      TNF-alpha can also activate osteoblastogenesis. The paradoxical role of TNF-alpha in bone 
      homeostasis seems to depend on the concentration and the differentiation state of 
      the cell type used as well as on the exposure time. This review aims to summarize 
      the recent contradictory findings on the regulation of bone homeostasis by TNF-alpha 
      at the isolated cell, whole bone, and whole body levels. In addition, the 
      involvement of TNF-alpha in the bone remodeling imbalance is observed in inflammatory 
      joint diseases including rheumatoid arthritis and ankylosing spondylitis, which 
      are associated with bone destruction and ectopic calcified matrix formation, 
      respectively. Both diseases are associated with systemic/vertebral osteoporosis.
FAU - Osta, Bilal
AU  - Osta B
AD  - Immunogenomics and Inflammation Research Unit EA 4130, Department of Immunology 
      and Rheumatology, Hospital Edouard Herriot, University of Lyon 1 , Lyon , France.
FAU - Benedetti, Giulia
AU  - Benedetti G
AD  - Immunogenomics and Inflammation Research Unit EA 4130, Department of Immunology 
      and Rheumatology, Hospital Edouard Herriot, University of Lyon 1 , Lyon , France.
FAU - Miossec, Pierre
AU  - Miossec P
AD  - Immunogenomics and Inflammation Research Unit EA 4130, Department of Immunology 
      and Rheumatology, Hospital Edouard Herriot, University of Lyon 1 , Lyon , France.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140213
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3923157
OTO - NOTNLM
OT  - TNF-alpha
OT  - ankylosing spondylitis
OT  - bone homeostasis
OT  - osteoblast
OT  - osteoclast
OT  - osteoporosis
OT  - rheumatoid arthritis
EDAT- 2014/03/05 06:00
MHDA- 2014/03/05 06:01
PMCR- 2014/01/01
CRDT- 2014/03/05 06:00
PHST- 2014/01/03 00:00 [received]
PHST- 2014/01/27 00:00 [accepted]
PHST- 2014/03/05 06:00 [entrez]
PHST- 2014/03/05 06:00 [pubmed]
PHST- 2014/03/05 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2014.00048 [doi]
PST - epublish
SO  - Front Immunol. 2014 Feb 13;5:48. doi: 10.3389/fimmu.2014.00048. eCollection 2014.