PMID- 24592310
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140304
LR  - 20211021
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 17
IP  - 1
DP  - 2014 Jan
TI  - Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury 
      induced by acute dose of ecstasy (MDMA) in mice.
PG  - 69-72
AB  - OBJECTIVE(S): Because of the high total phenolic contents of Feijoa sellowiana, 
      its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine 
      (MDMA) treated mice. MATERIALS AND METHODS: Animals received 10, 20 and 40 mg/kg 
      doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneally. 
      After one hour, an acute administration of MDMA (20 mg/kg, IP) was injected. 
      Nephroprotective effect was assayed by determination of serum creatinine, serum 
      urea and kidney glutathione level. Histopathological study was also used. Results 
      : Both extracts at 40 mg/kg resulted in a significant reversal in the raised 
      serum creatinine levels (P <0.05). Not statistically significant was observed in 
      effect of two extracts (P>0.05). A decrease in urea/ creatinine ratio was 
      observed following aqueous extract treatment. Methanolic extract showed higher 
      activity in increasing kidney glutathione (P<0.001 compared to MDMA group). 
      Methanol extract showed higher protective activity in histopathology study. 
      CONCLUSION: F. sellowiana extract resulted in a markedly decrease in the 
      nephrotoxicity of MDMA in mice.
FAU - Karami, Mohammad
AU  - Karami M
AD  - Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of 
      Medical Sciences, Sari, Iran.
FAU - Karimian Nokabadi, Faezeh
AU  - Karimian Nokabadi F
AD  - Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of 
      Medical Sciences, Sari, Iran.
FAU - Ebrahimzadeh, Mohammad Ali
AU  - Ebrahimzadeh MA
AD  - Department of Chemistry, School of Pharmacy, Mazandaran University of Medical 
      Sciences, Sari, Iran.
FAU - Naghshvar, Farshad
AU  - Naghshvar F
AD  - Department of Pathology, School of Medicine, Mazandaran University of Medical 
      Sciences, Sari, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC3938889
OTO - NOTNLM
OT  - Ecstasy
OT  - Feijoa sellowiana
OT  - Kidney glutathione
OT  - MDMA
OT  - Nephrotoxicity
EDAT- 2014/03/05 06:00
MHDA- 2014/03/05 06:01
PMCR- 2014/01/01
CRDT- 2014/03/05 06:00
PHST- 2013/02/22 00:00 [received]
PHST- 2013/08/23 00:00 [accepted]
PHST- 2014/03/05 06:00 [entrez]
PHST- 2014/03/05 06:00 [pubmed]
PHST- 2014/03/05 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - IJBMS-17-069 [pii]
PST - ppublish
SO  - Iran J Basic Med Sci. 2014 Jan;17(1):69-72.