PMID- 24592394
OWN - NLM
STAT- MEDLINE
DCOM- 20141015
LR  - 20211021
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2014
DP  - 2014
TI  - Neuroprotective effects of adipose-derived stem cells are maintained for 3 weeks 
      against ischemic damage in the rabbit spinal cord.
PG  - 539051
LID - 10.1155/2014/539051 [doi]
LID - 539051
AB  - In the previous study, we demonstrated that adipose-derived stem cells (ASCs) 
      have neuroprotective effects against ischemic damage in the ventral horn of L5-6 
      levels at 3 days after ischemia/reperfusion. In the present study, we expanded 
      our observations for 3 weeks after ischemia/reperfusion to rule out the 
      possibility of delayed neuronal death in several days after ischemia/reperfusion. 
      Transient spinal cord ischemia was induced by a 15 min aortic artery occlusion in 
      the subrenal region and rabbit ASCs were administered intrathecally into 
      recipient rabbits (2 x 10(5)) immediately after reperfusion. Transplantation of 
      ASCs improved the neurological motor functions of the hindlimb 3 weeks after 
      ischemia/reperfusion. Similarly, the cresyl violet-positive neurons were 
      significantly increased at 3 weeks after ischemia/reperfusion compared to that in 
      the vehicle (artificial cerebrospinal fluid)-treated group. The transplantation 
      of ASCs significantly reduced reactive microglia induced by ischemia at 3 weeks 
      after ischemia/reperfusion. In addition, transplantation of ASCs maintained the 
      brain-derived neurotrophic factor (BDNF) levels 3 weeks after 
      ischemia/reperfusion. These results suggest that the neuroprotective effects of 
      ASCs are maintained 3 weeks after ischemia/reperfusion by modulating microgliosis 
      and BDNF levels in the spinal cord.
FAU - Moon, Seung Myung
AU  - Moon SM
AD  - Department of Neurosurgery, Dongtan Sacred Heart Hospital, College of Medicine, 
      Hallym University, Hwaseong 445-170, Republic of Korea.
FAU - Kim, Woosuk
AU  - Kim W
AD  - Department of Anatomy and Cell Biology, College of Veterinary Medicine and 
      Research Institute for Veterinary Science, Seoul National University, Seoul 
      151-742, Republic of Korea.
FAU - Chung, Jin Young
AU  - Chung JY
AD  - Department of Veterinary Internal Medicine and Geriatrics, College of Veterinary 
      Medicine, Kangwon National University, Chuncheon 200-701, Republic of Korea.
FAU - Im, Wooseok
AU  - Im W
AD  - Department of Neurology, Seoul National University Hospital, Seoul 110-744, 
      Republic of Korea.
FAU - Yoo, Dae Young
AU  - Yoo DY
AD  - Department of Anatomy and Cell Biology, College of Veterinary Medicine and 
      Research Institute for Veterinary Science, Seoul National University, Seoul 
      151-742, Republic of Korea.
FAU - Jung, Hyo Young
AU  - Jung HY
AD  - Department of Anatomy and Cell Biology, College of Veterinary Medicine and 
      Research Institute for Veterinary Science, Seoul National University, Seoul 
      151-742, Republic of Korea.
FAU - Won, Moo-Ho
AU  - Won MH
AD  - Department of Neurobiology, School of Medicine, Kangwon National University, 
      Chuncheon 200-701, Republic of Korea.
FAU - Choi, Jung Hoon
AU  - Choi JH
AUID- ORCID: 0000-0002-3725-4907
AD  - Department of Anatomy, College of Veterinary Medicine, Kangwon National 
      University, Chuncheon 200-701, Republic of Korea.
FAU - Hwang, In Koo
AU  - Hwang IK
AUID- ORCID: 0000-0002-0533-4638
AD  - Department of Anatomy and Cell Biology, College of Veterinary Medicine and 
      Research Institute for Veterinary Science, Seoul National University, Seoul 
      151-742, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140129
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adipose Tissue/cytology
MH  - Animals
MH  - Aorta/pathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Ischemia/pathology/*therapy
MH  - Neuroprotective Agents
MH  - Rabbits
MH  - Reperfusion Injury/pathology/*therapy
MH  - Spinal Cord/pathology
MH  - *Stem Cell Transplantation
MH  - Stem Cells/*cytology
PMC - PMC3925622
EDAT- 2014/03/05 06:00
MHDA- 2014/10/16 06:00
PMCR- 2014/01/29
CRDT- 2014/03/05 06:00
PHST- 2013/07/04 00:00 [received]
PHST- 2013/12/16 00:00 [accepted]
PHST- 2014/03/05 06:00 [entrez]
PHST- 2014/03/05 06:00 [pubmed]
PHST- 2014/10/16 06:00 [medline]
PHST- 2014/01/29 00:00 [pmc-release]
AID - 10.1155/2014/539051 [doi]
PST - ppublish
SO  - Biomed Res Int. 2014;2014:539051. doi: 10.1155/2014/539051. Epub 2014 Jan 29.