PMID- 24593295
OWN - NLM
STAT- MEDLINE
DCOM- 20140825
LR  - 20211021
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 13
DP  - 2014 Mar 5
TI  - Correlation between n-3 polyunsaturated fatty acids consumption and BDNF 
      peripheral levels in adolescents.
PG  - 44
LID - 10.1186/1476-511X-13-44 [doi]
AB  - BACKGROUND: Although several studies have reported an association between mental 
      disorders and serum levels of brain-derived neurotrophic factor (BDNF), this 
      association is still poorly understood. The study of factors associated with both 
      BDNF levels and mental disorders, such as n-3 polyunsaturated fatty acids (n-3 
      PUFAs), may help to elucidate the mechanisms mediating the relationship between 
      the two variables. Therefore, the present study aimed to evaluate whether the 
      intake n-3 PUFAs correlates with serum levels of BDNF. FINDINGS: This study 
      involved 137 adolescents drawn from a community sample, including a group with 
      high levels of anxiety, assessed using the Screen for Children and Anxiety 
      Related Emotional Disorders. Blood samples were collected and serum BDNF levels 
      were measured. n-3 PUFAs were estimated using a food frequency questionnaire for 
      adolescents. Correlations were performed to assess the association between n-3 
      PUFAs intake and BDNF levels. Effects of potential confounders (total fat 
      consumption, age, gender and anxiety) were examined using linear regression 
      models. There was a direct correlation between n-3 PUFAs consumption and serum 
      BDNF levels, which remained significant even after accounting for potential 
      confounders. CONCLUSIONS: We were able to detect a correlation between n-3 PUFAs 
      intake and peripheral BDNF levels. Our study was limited by its small sample 
      size, and our external validity may be restricted by the oversampling of anxious 
      adolescents. Our findings may help determine the nature of the association 
      between mental disorders and serum levels of BDNF. However, more studies are 
      needed to elucidate the possible mechanisms by which n-3 PUFAs intake affects 
      BDNF levels, and how this may lead to an increased vulnerability to psychiatric 
      disorders.
FAU - Ferreira, Charles Francisco
AU  - Ferreira CF
AD  - Post Graduate Program in Neuroscience, Institute of Basic Sciences/Health, 
      Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. 
      neurocientista@hotmail.com.
FAU - Bernardi, Juliana Rombaldi
AU  - Bernardi JR
FAU - Bosa, Vera Lucia
AU  - Bosa VL
FAU - Schuch, Ilaine
AU  - Schuch I
FAU - Goldani, Marcelo Zubaran
AU  - Goldani MZ
FAU - Kapczinski, Flavio
AU  - Kapczinski F
FAU - Salum, Giovanni Abrahao
AU  - Salum GA
FAU - Dalmaz, Carla
AU  - Dalmaz C
FAU - Manfro, Gisele Gus
AU  - Manfro GG
FAU - Silveira, Patricia Pelufo
AU  - Silveira PP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140305
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Anxiety/*blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child
MH  - Diet
MH  - Fatty Acids, Omega-3/*physiology
MH  - Female
MH  - Humans
MH  - Male
PMC - PMC3974009
EDAT- 2014/03/07 06:00
MHDA- 2014/08/26 06:00
PMCR- 2014/03/05
CRDT- 2014/03/06 06:00
PHST- 2013/12/13 00:00 [received]
PHST- 2014/02/20 00:00 [accepted]
PHST- 2014/03/06 06:00 [entrez]
PHST- 2014/03/07 06:00 [pubmed]
PHST- 2014/08/26 06:00 [medline]
PHST- 2014/03/05 00:00 [pmc-release]
AID - 1476-511X-13-44 [pii]
AID - 10.1186/1476-511X-13-44 [doi]
PST - epublish
SO  - Lipids Health Dis. 2014 Mar 5;13:44. doi: 10.1186/1476-511X-13-44.