PMID- 24594243
OWN - NLM
STAT- MEDLINE
DCOM- 20141104
LR  - 20211021
IS  - 1824-7288 (Electronic)
IS  - 1720-8424 (Linking)
VI  - 40
IP  - 1
DP  - 2014 Mar 5
TI  - Pilot observational study on haemodynamic changes after surfactant administration 
      in preterm newborns with respiratory distress syndrome.
PG  - 26
LID - 10.1186/1824-7288-40-26 [doi]
AB  - BACKGROUND: Surfactant treatment reduces respiratory morbidity and mortality in 
      preterm infants. Data on its haemodynamic consequences are conflicting. The aim 
      was to characterise the haemodynamic effects of surfactant treatment on cardiac 
      function in preterm newborns with respiratory distress syndrome (RDS). METHODS: 
      Preterm infants (gestational age <34 weeks, birth weight <2000 g) with RDS, who 
      received surfactant within 72 hours of life, were recruited.Echocardiography was 
      performed before surfactant, and 2 and 24 hours after. Left and right ventricular 
      peak systolic, early diastolic and late diastolic myocardial velocities were 
      measured using Tissue Doppler Imaging (TDI), while characteristics of the ductus 
      arteriosus, pulmonary artery pressure, right ventricular (RVO) and left 
      ventricular output were measured by standard echocardiography. Tricuspidal 
      Annular Plane Systolic Excursion (TAPSE) was measured on the free wall of the 
      tricuspid annulus. RESULTS: Fourteen patients were studied. Surfactant was 
      associated with a decrease in pulmonary pressure and an increase in RVO. The 
      improvement of right ventricular function was also confirmed by a significant 
      increase in right peak systolic velocity and in TAPSE. Left ventricular 
      velocities did not change significantly after surfactant. CONCLUSIONS: Surfactant 
      administration in preterm infants with RDS did not impair myocardial 
      contractility and was followed by increased RVO, in agreement with other 
      parameters of right ventricular function. TDI and TAPSE appeared to be reliable 
      and feasible in this population. The addition of TDI and TAPSE to standard 
      neonatal echocardiography may provide additional information about cardiac 
      function.
FAU - Vitali, Francesca
AU  - Vitali F
FAU - Galletti, Silvia
AU  - Galletti S
AD  - Neonatology and Neonatal Intensive Care Unit, S, Orsola-Malpighi Hospital, 
      University of Bologna, Bologna, Italy. silvia.galletti4@unibo.it.
FAU - Aceti, Arianna
AU  - Aceti A
FAU - Aquilano, Giulia
AU  - Aquilano G
FAU - Fabi, Marianna
AU  - Fabi M
FAU - Balducci, Anna
AU  - Balducci A
FAU - Faldella, Giacomo
AU  - Faldella G
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20140305
PL  - England
TA  - Ital J Pediatr
JT  - Italian journal of pediatrics
JID - 101510759
RN  - 0 (Pulmonary Surfactants)
SB  - IM
MH  - Dose-Response Relationship, Drug
MH  - Echocardiography, Doppler, Pulsed
MH  - Female
MH  - Follow-Up Studies
MH  - Gestational Age
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Infant, Premature, Diseases/diagnostic imaging/*drug therapy/physiopathology
MH  - Male
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Pulmonary Surfactants/*administration & dosage
MH  - Respiratory Distress Syndrome, Newborn/diagnostic imaging/*drug 
      therapy/physiopathology
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ventricular Function, Right/*physiology
PMC - PMC3984744
EDAT- 2014/03/07 06:00
MHDA- 2014/11/05 06:00
PMCR- 2014/03/05
CRDT- 2014/03/06 06:00
PHST- 2013/09/21 00:00 [received]
PHST- 2014/02/26 00:00 [accepted]
PHST- 2014/03/06 06:00 [entrez]
PHST- 2014/03/07 06:00 [pubmed]
PHST- 2014/11/05 06:00 [medline]
PHST- 2014/03/05 00:00 [pmc-release]
AID - 1824-7288-40-26 [pii]
AID - 10.1186/1824-7288-40-26 [doi]
PST - epublish
SO  - Ital J Pediatr. 2014 Mar 5;40(1):26. doi: 10.1186/1824-7288-40-26.