PMID- 24595503
OWN - NLM
STAT- MEDLINE
DCOM- 20150804
LR  - 20240504
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 231
IP  - 16
DP  - 2014 Aug
TI  - Effects of Mindfulness-Oriented Recovery Enhancement on reward responsiveness and 
      opioid cue-reactivity.
PG  - 3229-38
LID - 10.1007/s00213-014-3504-7 [doi]
AB  - RATIONALE: Dysregulated reward processing is a hallmark feature of drug 
      addiction; however, scant research has evaluated restructuring reward processing 
      in the context of addiction treatment. OBJECTIVES: We examined effects of 
      Mindfulness-Oriented Recovery Enhancement (MORE) on reward responsiveness (RR) 
      and opioid cue-reactivity in a sample of chronic pain patients with opioid use 
      problems. We previously reported that MORE decreased pain, opioid misuse, and 
      craving relative to a social support control group (SG). Here, we examined 
      whether these outcomes were linked to changes in RR in a subset of participants. 
      METHODS: Participants were chronic pain patients (71 % women, age 46.6 +/- 13.9) 
      who received MORE (n = 20) or SG (n = 29). RR was measured before and after 8 
      weeks of treatment via heart rate (HR) and heart rate variability (HRV) responses 
      during a dot probe task that included opioid-related, pain-related, and natural 
      reward stimuli, as well as craving ratings. RESULTS: The MORE group, who reported 
      decreased opioid misuse and opioid craving during treatment, evidenced less 
      subjective opioid cue-reactivity, greater HR decelerations, and greater increases 
      in HRV to all cues after treatment compared to the SG; HR and HRV effects were 
      most pronounced for natural reward cues. Within the MORE group, HR deceleration 
      to natural reward cues was correlated with increased subjective arousal to the 
      cues, whereas HR deceleration to opioid cues was correlated with decreased 
      subjective arousal. Effects of MORE on craving were mediated by enhanced RR. 
      CONCLUSIONS: Results suggest that during treatment with MORE, cardiac-autonomic 
      responsiveness to non-drug reward increases, while reactivity to opioid reward 
      decreases. Studies are needed to discern whether changes in RR were a result or a 
      determinant of reductions in opioid misuse and craving. RR may play a role in 
      addiction treatment.
FAU - Garland, Eric L
AU  - Garland EL
AD  - College of Social Work and Huntsman Cancer Institute, University of Utah, 395 
      South, 1500 East, Salt Lake City, UT, 84112, USA, elgarlan@gmail.com.
FAU - Froeliger, Brett
AU  - Froeliger B
FAU - Howard, Matthew O
AU  - Howard MO
LA  - eng
GR  - R03 DA032517/DA/NIDA NIH HHS/United States
GR  - R34 DA037005/DA/NIDA NIH HHS/United States
GR  - DA037005/DA/NIDA NIH HHS/United States
GR  - DA032517/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140305
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
SB  - IM
MH  - Adult
MH  - Affect
MH  - Arousal
MH  - Attention
MH  - Chronic Pain/complications/psychology/rehabilitation
MH  - Cues
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Mindfulness
MH  - Opioid-Related Disorders/psychology/*rehabilitation
MH  - Prescription Drug Misuse/psychology
MH  - Reward
MH  - Self Report
PMC - PMC4111972
MID - NIHMS572815
COIS- Conflict of Interest: None
EDAT- 2014/03/07 06:00
MHDA- 2015/08/05 06:00
PMCR- 2015/08/01
CRDT- 2014/03/06 06:00
PHST- 2013/11/16 00:00 [received]
PHST- 2014/02/08 00:00 [accepted]
PHST- 2014/03/06 06:00 [entrez]
PHST- 2014/03/07 06:00 [pubmed]
PHST- 2015/08/05 06:00 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - 10.1007/s00213-014-3504-7 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2014 Aug;231(16):3229-38. doi: 
      10.1007/s00213-014-3504-7. Epub 2014 Mar 5.