PMID- 24595886
OWN - NLM
STAT- MEDLINE
DCOM- 20141124
LR  - 20140313
IS  - 1477-0539 (Electronic)
IS  - 1477-0520 (Linking)
VI  - 12
IP  - 14
DP  - 2014 Apr 14
TI  - Direct sp3 C-H bond arylation, alkylation, and amidation of 
      tetrahydroisoquinolines mediated by hypervalent iodine(III) under mild 
      conditions.
PG  - 2189-92
LID - 10.1039/c3ob42354a [doi]
AB  - We have developed a method for the sp(3) C-H bond functionalization of 
      tetrahydroisoquinolines (THIQs) mediated by [bis(trifluoroacetoxy)iodo]benzene 
      (PIFA). The treatment of the THIQs with various nucleophiles in the presence of 
      PIFA in a green solvent alternative gave the coupled products, with a C-C, C-N, 
      or quaternary carbon center in high yields.
FAU - Muramatsu, Wataru
AU  - Muramatsu W
AD  - Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, 
      Nagasaki, Nagasaki 852-8521, Japan. muramatu@nagasaki-u.ac.jp.
FAU - Nakano, Kimihiro
AU  - Nakano K
FAU - Li, Chao-Jun
AU  - Li CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Org Biomol Chem
JT  - Organic & biomolecular chemistry
JID - 101154995
RN  - 0 (Amides)
RN  - 0 (Tetrahydroisoquinolines)
RN  - 9679TC07X4 (Iodine)
SB  - IM
MH  - Alkylation
MH  - Amides/*chemical synthesis/chemistry
MH  - Iodine/*chemistry
MH  - Molecular Structure
MH  - Tetrahydroisoquinolines/*chemistry
EDAT- 2014/03/07 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/03/06 06:00
PHST- 2014/03/06 06:00 [entrez]
PHST- 2014/03/07 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1039/c3ob42354a [doi]
PST - ppublish
SO  - Org Biomol Chem. 2014 Apr 14;12(14):2189-92. doi: 10.1039/c3ob42354a.