PMID- 24596618
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1976-9148 (Print)
IS  - 2005-4483 (Electronic)
IS  - 1976-9148 (Linking)
VI  - 22
IP  - 1
DP  - 2014 Jan
TI  - Curcumin inhibits the activation of immunoglobulin e-mediated mast cells and 
      passive systemic anaphylaxis in mice by reducing serum eicosanoid and histamine 
      levels.
PG  - 27-34
LID - 10.4062/biomolther.2013.092 [doi]
AB  - Curcumin is naturally occurring polyphenolic compound found in turmeric and has 
      many pharmacological activities. The present study was undertaken to evaluate 
      anti-allergic inflammatory activity of curcumin, and to investigate its 
      inhibitory mechanisms in immunoglobulin E (IgE)/Ag-induced mouse bone 
      marrow-derived mast cells (BMMCs) and in a mouse model of IgE/Ag-mediated passive 
      systemic anaphylaxis (PSA). Curcumin inhibited cyclooxygenase-2 (COX-2) dependent 
      prostaglandin D2 (PGD2) and 5-lipoxygenase (5-LO) dependent leukotriene C4 (LTC4) 
      generation dose-dependently in BMMCs. To probe the mechanism involved, we 
      assessed the effects of curcumin on the phosphorylation of Syk and its downstream 
      signal molecules. Curcumin inhibited intracellular Ca(2+) influx via 
      phospholipase Cgamma1 (PLCgamma1) activation and the phosphorylation of mitogen-activated 
      protein kinases (MAPKs) and the nuclear factor-kappaB (NF-kappaB) pathway. Furthermore, 
      the oral administration of curcumin significantly attenuated IgE/Ag-induced PSA, 
      as determined by serum LTC4, PGD2, and histamine levels. Taken together, this 
      study shows that curcumin offers a basis for drug development for the treatment 
      of allergic inflammatory diseases.
FAU - Li, Xian
AU  - Li X
AD  - College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
FAU - Lu, Yue
AU  - Lu Y
AD  - School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 
      201203, China.
FAU - Jin, Ye
AU  - Jin Y
AD  - College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
FAU - Son, Jong-Keun
AU  - Son JK
AD  - College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
FAU - Lee, Seung Ho
AU  - Lee SH
AD  - College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
FAU - Chang, Hyeun Wook
AU  - Chang HW
AD  - College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Biomol Ther (Seoul)
JT  - Biomolecules & therapeutics
JID - 101472832
PMC - PMC3936421
OTO - NOTNLM
OT  - Curcumin
OT  - Leukotriene C4
OT  - Mast cell
OT  - Mitogen activated protein kinase
OT  - Passive systemic anaphylaxis
OT  - Prostaglandin D2
EDAT- 2014/03/07 06:00
MHDA- 2014/03/07 06:01
PMCR- 2014/01/01
CRDT- 2014/03/06 06:00
PHST- 2013/11/01 00:00 [received]
PHST- 2013/12/09 00:00 [revised]
PHST- 2013/12/11 00:00 [accepted]
PHST- 2014/03/06 06:00 [entrez]
PHST- 2014/03/07 06:00 [pubmed]
PHST- 2014/03/07 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 27-34_bt22-1 [pii]
AID - 10.4062/biomolther.2013.092 [doi]
PST - ppublish
SO  - Biomol Ther (Seoul). 2014 Jan;22(1):27-34. doi: 10.4062/biomolther.2013.092.