PMID- 24597930
OWN - NLM
STAT- MEDLINE
DCOM- 20151201
LR  - 20220330
IS  - 1447-0594 (Electronic)
IS  - 1447-0594 (Linking)
VI  - 15
IP  - 3
DP  - 2015 Mar
TI  - Factors associated with cognitive decline in older adults with type 2 diabetes 
      mellitus during a 6-year observation.
PG  - 302-10
LID - 10.1111/ggi.12273 [doi]
AB  - AIMS: Type 2 diabetes mellitus (T2DM) is a risk for cognitive decline in older 
      adults. The current study was carried out to determine the factors associated 
      with cognitive decline. METHODS: The older T2DM patients (aged >/=65 years, mean 
      age 79.2 +/- 5.1 years) were observed for 6 years, and the mean values in clinical 
      indicators of participants with and without cognitive decline over a 6-year 
      period were compared. Then, multiple logistic analysis was carried out to 
      determine the factors associated with cognitive decline. Separate analyses were 
      also carried out for each of five cognitive assessments (Mini-Mental State 
      Examination, word immediate and delayed recall, Stroop test, digit symbol 
      substitution). RESULTS: In the composite of several cognitive assessments, higher 
      age and a lower level of high-density lipoprotein cholesterol were associated 
      with cognitive decline in older T2DM patients. Lower systolic blood pressure was 
      associated with a decline in delayed word list recall. Higher plasma insulin 
      level was associated with a decline in the Stroop test performance. CONCLUSION: 
      Lower high-density lipoprotein cholesterol was significantly associated with 
      general cognitive decline in older T2DM patients during our 6-year observation. 
      Several other factors were also associated with cognitive assessments of various 
      cognitive domains.
CI  - (c) 2014 Japan Geriatrics Society.
FAU - Umegaki, Hiroyuki
AU  - Umegaki H
AD  - Department of Community Healthcare & Geriatrics, Nagoya University Graduate 
      School of Medicine, Nagoya, Japan.
FAU - Kawamura, Takahiko
AU  - Kawamura T
FAU - Umemura, Toshitaka
AU  - Umemura T
FAU - Kawano, Naoko
AU  - Kawano N
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20140305
PL  - Japan
TA  - Geriatr Gerontol Int
JT  - Geriatrics & gerontology international
JID - 101135738
RN  - 0 (Insulin)
SB  - IM
MH  - Aged
MH  - Cognition/*physiology
MH  - Cognition Disorders/epidemiology/*etiology/psychology
MH  - Diabetes Mellitus, Type 2/blood/*complications/psychology
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - *Geriatric Assessment
MH  - Humans
MH  - Incidence
MH  - Insulin/blood
MH  - Japan/epidemiology
MH  - Male
MH  - Risk Assessment/*methods
MH  - Risk Factors
MH  - Time Factors
OTO - NOTNLM
OT  - blood pressure
OT  - hemoglobin A1c
OT  - high-density lipoprotein cholesterol
OT  - insulin
OT  - renin-angiotensin system blockers
EDAT- 2014/03/07 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/03/07 06:00
PHST- 2014/01/21 00:00 [accepted]
PHST- 2014/03/07 06:00 [entrez]
PHST- 2014/03/07 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1111/ggi.12273 [doi]
PST - ppublish
SO  - Geriatr Gerontol Int. 2015 Mar;15(3):302-10. doi: 10.1111/ggi.12273. Epub 2014 
      Mar 5.