PMID- 24599623 OWN - NLM STAT- MEDLINE DCOM- 20141110 LR - 20211021 IS - 1432-1084 (Electronic) IS - 0938-7994 (Linking) VI - 24 IP - 6 DP - 2014 Jun TI - Evaluation of monoenergetic late iodine enhancement dual-energy computed tomography for imaging of chronic myocardial infarction. PG - 1211-8 LID - 10.1007/s00330-014-3126-9 [doi] AB - OBJECTIVES: To evaluate image quality and diagnostic accuracy of selective monoenergetic reconstructions of late iodine enhancement (LIE) dual-energy computed tomography (DECT) for imaging of chronic myocardial infarction (CMI). METHODS: Twenty patients with a history of coronary bypass surgery underwent cardiac LIE-DECT and late gadolinium enhancement (LGE) magnetic resonance imaging (MRI). LIE-DECT images were reconstructed as selective monoenergetic spectral images with photon energies of 40, 60, 80, and 100 keV and the standard linear blending setting (M_0.6). Images were assessed for late enhancement, transmural extent, signal characteristics and subjective image quality. RESULTS: Seventy-nine myocardial segments (23 %) showed LGE. LIE-DECT detected 76 lesions. Images obtained at 80 keV and M_0.6 showed a high signal-to-noise ratio (15.9; 15.1), contrast-to-noise ratio (4.2; 4.0) and sensitivity (94.9 %; 92.4 %) while specificity was identical (99.6 %). Differences between these series were not statistically significant. Transmural extent of LIE was overestimated in both series (80 keV: 40 %; M_0.6: 35 %) in comparison to MRI. However, observers preferred 80 keV in 13/20 cases (65 %, kappa = 0.634) over M_0.6 (4/20 cases) regarding subjective image quality. CONCLUSIONS: Post-processing of LIE-DECT data with selective monoenergetic reconstructions at 80 keV significantly improves subjective image quality while objective image quality shows no significant difference compared to standard linear blending. KEY POINTS: Late enhancement dual-energy CT allows for detection of chronic myocardial infarction. Monoenergetic reconstructions at 80 keV significantly improve subjective image quality. 80 keV and standard linear blending reconstructions show no significant differences. Extent of CMI detected with LIE-DECT is overestimated compared with MRI. FAU - Wichmann, Julian L AU - Wichmann JL AD - Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany, docwichmann@gmail.com. FAU - Arbaciauskaite, Ruta AU - Arbaciauskaite R FAU - Kerl, J Matthias AU - Kerl JM FAU - Frellesen, Claudia AU - Frellesen C FAU - Bodelle, Boris AU - Bodelle B FAU - Lehnert, Thomas AU - Lehnert T FAU - Monsefi, Nadejda AU - Monsefi N FAU - Vogl, Thomas J AU - Vogl TJ FAU - Bauer, Ralf W AU - Bauer RW LA - eng PT - Clinical Trial PT - Journal Article DEP - 20140306 PL - Germany TA - Eur Radiol JT - European radiology JID - 9114774 RN - 0 (Contrast Media) RN - 9679TC07X4 (Iodine) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Aged MH - Chronic Disease MH - Contrast Media MH - Coronary Artery Bypass MH - Female MH - Gadolinium MH - Humans MH - Image Enhancement/*methods MH - *Iodine MH - Magnetic Resonance Imaging/methods MH - Male MH - Middle Aged MH - Myocardial Infarction/*diagnostic imaging/surgery MH - Predictive Value of Tests MH - Prospective Studies MH - Sensitivity and Specificity MH - Signal-To-Noise Ratio MH - Tomography, X-Ray Computed/*methods EDAT- 2014/03/07 06:00 MHDA- 2014/11/11 06:00 CRDT- 2014/03/07 06:00 PHST- 2013/10/30 00:00 [received] PHST- 2014/02/12 00:00 [accepted] PHST- 2014/02/06 00:00 [revised] PHST- 2014/03/07 06:00 [entrez] PHST- 2014/03/07 06:00 [pubmed] PHST- 2014/11/11 06:00 [medline] AID - 10.1007/s00330-014-3126-9 [doi] PST - ppublish SO - Eur Radiol. 2014 Jun;24(6):1211-8. doi: 10.1007/s00330-014-3126-9. Epub 2014 Mar 6.