PMID- 24600221
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20211021
IS  - 1178-2013 (Electronic)
IS  - 1176-9114 (Print)
IS  - 1176-9114 (Linking)
VI  - 9
DP  - 2014
TI  - The therapeutic effect of monocyte chemoattractant protein-1 delivered by an 
      electrospun scaffold for hyperglycemia and nephrotic disorders.
PG  - 985-93
LID - 10.2147/IJN.S55812 [doi]
AB  - Here, we investigated in diabetic mice the therapeutic effect of monocyte 
      chemoattractant protein-1 (MCP-1), locally delivered by an electrospun scaffold, 
      on transplanted islets. This therapeutic scheme is expected to exert a 
      synergistic effect to ameliorate hyperglycemia and its associated nephrotic 
      disorders. The cumulative amount of MCP-1 released from the scaffold in vitro 
      within a 3-week window was 267.77 +/- 32.18 ng, without a compromise in 
      bioactivity. After 8 weeks following the transplantation, the islet population 
      stimulated by MCP-1 was 35.14%+/- 7.23% larger than the non-stimulated islet 
      population. Moreover, MCP-1 increased concentrations of blood insulin and 
      C-peptide 2 by 49.83%+/- 5.29% and 43.49%+/- 9.21%, respectively. Consequently, the 
      blood glucose concentration in the MCP-1 group was significantly lower than that 
      in the control group at week 2 post-surgery. MCP-1 also enhanced the tolerance of 
      sudden oral glucose challenge. The rapid decrease of blood creatinine, urine 
      creatinine, and blood urea nitrogen suggested that the recovery of renal 
      functions compromised by hyperglycemia could also be attributed to MCP-1. Our 
      study shed new light on a synergistic strategy to alleviate hyperglycemia and 
      nephrotic disorders in diabetic patients.
FAU - Yong, Cai
AU  - Yong C
AD  - Department of Transplantation, First Affiliated Hospital of Wenzhou Medical 
      College, Wenzhou, People's Republic of China.
FAU - Wang, Zhengxin
AU  - Wang Z
AD  - Department of Surgery, Organ Transplant Center, Shanghai Changzheng Hospital, 
      Second Military Medical University, Shanghai, People's Republic of China.
FAU - Zhang, Xing
AU  - Zhang X
AD  - Department of Surgery, University of Chicago, Chicago, IL, USA.
FAU - Shi, Xiaomin
AU  - Shi X
AD  - Department of Surgery, Organ Transplant Center, Shanghai Changzheng Hospital, 
      Second Military Medical University, Shanghai, People's Republic of China.
FAU - Ni, Zhijia
AU  - Ni Z
AD  - Department of Surgery, Organ Transplant Center, Shanghai Changzheng Hospital, 
      Second Military Medical University, Shanghai, People's Republic of China.
FAU - Fu, Hong
AU  - Fu H
AD  - Department of Surgery, Organ Transplant Center, Shanghai Changzheng Hospital, 
      Second Military Medical University, Shanghai, People's Republic of China.
FAU - Ding, Guoshan
AU  - Ding G
AD  - Department of Surgery, Organ Transplant Center, Shanghai Changzheng Hospital, 
      Second Military Medical University, Shanghai, People's Republic of China.
FAU - Fu, Zhiren
AU  - Fu Z
AD  - Department of Surgery, Organ Transplant Center, Shanghai Changzheng Hospital, 
      Second Military Medical University, Shanghai, People's Republic of China.
FAU - Yin, Hao
AU  - Yin H
AD  - Department of Surgery, Organ Transplant Center, Shanghai Changzheng Hospital, 
      Second Military Medical University, Shanghai, People's Republic of China ; 
      Department of Surgery, University of Chicago, Chicago, IL, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140217
PL  - New Zealand
TA  - Int J Nanomedicine
JT  - International journal of nanomedicine
JID - 101263847
RN  - 0 (Blood Glucose)
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Chemokine CCL2/*administration & dosage/genetics/pharmacokinetics
MH  - Diabetes Mellitus, Experimental/blood/*therapy
MH  - Diabetic Nephropathies/physiopathology/therapy
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Hyperglycemia/blood/therapy
MH  - *Islets of Langerhans Transplantation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Nanomedicine
MH  - Tissue Engineering
MH  - Tissue Scaffolds/chemistry
PMC - PMC3933709
OTO - NOTNLM
OT  - MCP-1
OT  - diabetes
OT  - electrospinning
OT  - islet transplantation
EDAT- 2014/03/07 06:00
MHDA- 2015/05/12 06:00
PMCR- 2014/02/17
CRDT- 2014/03/07 06:00
PHST- 2014/03/07 06:00 [entrez]
PHST- 2014/03/07 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
PHST- 2014/02/17 00:00 [pmc-release]
AID - ijn-9-985 [pii]
AID - 10.2147/IJN.S55812 [doi]
PST - epublish
SO  - Int J Nanomedicine. 2014 Feb 17;9:985-93. doi: 10.2147/IJN.S55812. eCollection 
      2014.