PMID- 24600454
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140620
LR  - 20211022
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 5
DP  - 2014
TI  - The role of dendritic cells in graft-versus-tumor effect.
PG  - 66
LID - 10.3389/fimmu.2014.00066 [doi]
LID - 66
AB  - Dendritic cells (DCs) are the most potent antigen presenting cells. DCs play a 
      pivotal role in determining the character and magnitude of immune responses to 
      tumors. Host and donor hematopoietic-derived DCs play a critical role in the 
      development of graft-versus-host disease (GVHD) following allogeneic 
      hematopoietic cell transplantation. GVHD is tightly linked with the 
      graft-versus-tumor (GVT) effect. Although both host and donor DCs are important 
      regulators of GVHD, the role of DCs in GVT is poorly understood. GVT is caused by 
      donor T cells that attack recipient tumor cells. The donor T cells recognize 
      alloantigens, and tumor specific antigens (TSAs) are mediating GVHD. The process 
      of presentation of these antigens, especially TSAs remains unknown. Recent data 
      suggested that DC may be essential role for inducing GVT. The mechanisms that DCs 
      possess may include direct presentation, cross-presentation, cross-dressing. The 
      role they play in GVT will be reviewed.
FAU - Toubai, Tomomi
AU  - Toubai T
AD  - Blood and Marrow Transplantation Program, Division of Hematology and Oncology, 
      Department of Internal Medicine, University of Michigan Comprehensive Cancer 
      Center , Ann Arbor, MI , USA.
FAU - Mathewson, Nathan
AU  - Mathewson N
AD  - Blood and Marrow Transplantation Program, Division of Hematology and Oncology, 
      Department of Internal Medicine, University of Michigan Comprehensive Cancer 
      Center , Ann Arbor, MI , USA.
FAU - Reddy, Pavan
AU  - Reddy P
AD  - Blood and Marrow Transplantation Program, Division of Hematology and Oncology, 
      Department of Internal Medicine, University of Michigan Comprehensive Cancer 
      Center , Ann Arbor, MI , USA.
LA  - eng
GR  - R01 HL090775/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20140221
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3930914
OTO - NOTNLM
OT  - allogeneic hematopoietic stem cell transplantation
OT  - dendritic cells
OT  - graft-versus-tumor effect
EDAT- 2014/03/07 06:00
MHDA- 2014/03/07 06:01
PMCR- 2014/01/01
CRDT- 2014/03/07 06:00
PHST- 2013/11/05 00:00 [received]
PHST- 2014/02/05 00:00 [accepted]
PHST- 2014/03/07 06:00 [entrez]
PHST- 2014/03/07 06:00 [pubmed]
PHST- 2014/03/07 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2014.00066 [doi]
PST - epublish
SO  - Front Immunol. 2014 Feb 21;5:66. doi: 10.3389/fimmu.2014.00066. eCollection 2014.