PMID- 24601738
OWN - NLM
STAT- MEDLINE
DCOM- 20150416
LR  - 20140802
IS  - 1557-7465 (Electronic)
IS  - 1079-9907 (Linking)
VI  - 34
IP  - 8
DP  - 2014 Aug
TI  - Cell-based delivery of brain-derived neurotrophic factor in experimental allergic 
      encephalomyelitis.
PG  - 641-7
LID - 10.1089/jir.2013.0160 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a pleiotropic cytokine with 
      neuroprotective properties that has been identified as a potential therapeutic 
      agent for diseases of the central nervous system (CNS). The use of BDNF has been 
      limited by a short serum half-life and poor penetration of the blood-brain 
      barrier. To address this limitation we have explored cell-based approaches to 
      delivery. We have used experimental allergic encephalomyelitis (EAE), an 
      inflammatory disease of the CNS, as a model system. We engineered hematopoietic 
      stem cells to produce BDNF to determine the feasibility and effectiveness of 
      cell-based delivery of BDNF into the CNS in EAE. We review those studies here.
FAU - Makar, Tapas K
AU  - Makar TK
AD  - 1 Multiple Sclerosis Center of Excellence-East , Department of Veterans Affairs 
      Maryland Health Care System, Baltimore, Maryland.
FAU - Nimmagadda, Vamshi K C
AU  - Nimmagadda VK
FAU - Trisler, David
AU  - Trisler D
FAU - Bever, Christopher T Jr
AU  - Bever CT Jr
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140306
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism/*therapeutic use
MH  - Cell Movement
MH  - Cells, Cultured
MH  - Central Nervous System/*drug effects
MH  - Cytokines/metabolism
MH  - Drug Delivery Systems
MH  - Encephalomyelitis, Autoimmune, Experimental/immunology/*therapy
MH  - Genetic Engineering
MH  - Hematopoietic Stem Cell Transplantation
MH  - Hematopoietic Stem Cells/*physiology
MH  - Humans
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Neuroprotective Agents/*therapeutic use
MH  - Transgenes/genetics
MH  - Up-Regulation
EDAT- 2014/03/08 06:00
MHDA- 2015/04/17 06:00
CRDT- 2014/03/08 06:00
PHST- 2014/03/08 06:00 [entrez]
PHST- 2014/03/08 06:00 [pubmed]
PHST- 2015/04/17 06:00 [medline]
AID - 10.1089/jir.2013.0160 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2014 Aug;34(8):641-7. doi: 10.1089/jir.2013.0160. Epub 
      2014 Mar 6.