PMID- 24602085
OWN - NLM
STAT- MEDLINE
DCOM- 20140628
LR  - 20220310
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1311
DP  - 2014 Apr
TI  - Gastrointestinal morbidity in obesity.
PG  - 42-56
LID - 10.1111/nyas.12385 [doi]
AB  - Obesity is a complex disease that results from increased energy intake and 
      decreased energy expenditure. The gastrointestinal system plays a key role in the 
      pathogenesis of obesity and facilitates caloric imbalance. Changes in 
      gastrointestinal hormones and the inhibition of mechanisms that curtail caloric 
      intake result in weight gain. It is not clear if the gastrointestinal role in 
      obesity is a cause or an effect of this disease. Obesity is often associated with 
      type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Obesity is also 
      associated with gastrointestinal disorders, which are more frequent and present 
      earlier than T2DM and CVD. Diseases such as gastroesophageal reflux disease 
      (GERD), cholelithiasis, or nonalcoholic steatohepatitis are directly related to 
      body weight and abdominal adiposity. Our objective is to assess the role of each 
      gastrointestinal organ in obesity and the gastrointestinal morbidity resulting in 
      those organs from the effects of obesity.
CI  - (c) 2014 New York Academy of Sciences.
FAU - Acosta, Andres
AU  - Acosta A
AD  - Clinical Enteric Neuroscience Translational and Epidemiological Research 
      (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Department of 
      Medicine, Mayo Clinic, Rochester, Minnesota.
FAU - Camilleri, Michael
AU  - Camilleri M
LA  - eng
GR  - R01 DK067071/DK/NIDDK NIH HHS/United States
GR  - T32 DK007198/DK/NIDDK NIH HHS/United States
GR  - R01-DK67071/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20140306
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Body Weight/*physiology
MH  - Cardiovascular Diseases/complications/physiopathology
MH  - Diabetes Mellitus, Type 2/complications/physiopathology
MH  - Energy Intake/*physiology
MH  - Gastroesophageal Reflux/complications/physiopathology
MH  - Gastrointestinal Tract/*physiopathology
MH  - Humans
MH  - Obesity/*physiopathology
MH  - Satiety Response/*physiology
PMC - PMC4122663
MID - NIHMS559520
OTO - NOTNLM
OT  - GERD
OT  - appetite
OT  - cancer
OT  - diarrhea
OT  - gastrointestinal
OT  - obesity
COIS- Disclosures: There are no conflicts of interest.
EDAT- 2014/03/08 06:00
MHDA- 2014/06/29 06:00
PMCR- 2014/08/05
CRDT- 2014/03/08 06:00
PHST- 2014/03/08 06:00 [entrez]
PHST- 2014/03/08 06:00 [pubmed]
PHST- 2014/06/29 06:00 [medline]
PHST- 2014/08/05 00:00 [pmc-release]
AID - 10.1111/nyas.12385 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2014 Apr;1311:42-56. doi: 10.1111/nyas.12385. Epub 2014 Mar 6.