PMID- 24603290
OWN - NLM
STAT- MEDLINE
DCOM- 20150202
LR  - 20201209
IS  - 1530-0447 (Electronic)
IS  - 0031-3998 (Linking)
VI  - 75
IP  - 6
DP  - 2014 Jun
TI  - Balanced duo of anti-inflammatory SFRP5 and proinflammatory WNT5A in children.
PG  - 793-7
LID - 10.1038/pr.2014.29 [doi]
AB  - BACKGROUND: Secreted frizzled-related protein 5 (SFRP5) is an adipokine 
      protecting against obesity-related insulin resistance and diabetes. SFRP5 binds 
      to wingless type mouse mammary tumor virus (MMTV) integration site family member 
      5A (WNT5A) to improve insulin sensitivity. We performed the first study of SFRP5 
      and WNT5A simultaneously in children. METHODS: Prepubertal children (n = 342) 
      were assessed for circulating SFRP5 (all subjects) and circulating WNT5A (210 
      subjects), and associations were sought with metabolic markers. In conditioned 
      media of adipose tissue explants from 12 additional children, SFRP5 and WNT5A 
      were studied further. RESULTS: The concentrations of SFRP5 and WNT5A correlated 
      positively in serum and in conditioned media (all P < 0.001). Lower level of 
      circulating SFRP5 (lowest quartile) was associated with higher BMI (15% increase, 
      P < 0.0001) and lower level of high-molecular-weight adiponectin (26% decrease, P 
      = 0.002). Circulating WNT5A related closely with insulin resistance assessed by 
      the homeostasis model assessment for insulin resistance and hepatic markers 
      (alanine transaminase and gamma glutamyl transpeptidase), particularly in 
      children with lower circulating SFRP5 levels (all P < 0.004). CONCLUSION: SFRP5 
      and WNT5A comprise a balanced duo that may regulate metabolic homeostasis in 
      prepubertal children.
FAU - Prats-Puig, Anna
AU  - Prats-Puig A
AD  - 1] Pediatrics Research Group, Girona Institute for Biomedical Research, Girona, 
      Spain [2] Department of Pediatrics, Dr Josep Trueta Hospital, Girona, Spain.
FAU - Soriano-Rodriguez, Pilar
AU  - Soriano-Rodriguez P
AD  - Clinical Laboratory Salut Emporda Foundation, Figueres, Spain.
FAU - Carreras-Badosa, Gemma
AU  - Carreras-Badosa G
AD  - 1] Pediatrics Research Group, Girona Institute for Biomedical Research, Girona, 
      Spain [2] Department of Pediatrics, Dr Josep Trueta Hospital, Girona, Spain.
FAU - Riera-Perez, Elena
AU  - Riera-Perez E
AD  - Department of Pediatrics, Salut Emporda Foundation, Figueres, Spain.
FAU - Ros-Miquel, Monserrat
AU  - Ros-Miquel M
AD  - Department of Pediatric Surgery, Dr Josep Trueta Hospital, Girona, Spain.
FAU - Gomila-Borja, Antoni
AU  - Gomila-Borja A
AD  - Department of Pediatric Surgery, Dr Josep Trueta Hospital, Girona, Spain.
FAU - de Zegher, Francis
AU  - de Zegher F
AD  - Department of Development & Regeneration, University of Leuven, Leuven, Belgium.
FAU - Ibanez, Lourdes
AU  - Ibanez L
AD  - 1] Department of Pediatric Endocrinology, Sant Joan de Deu Children's Hospital, 
      Esplugues, Barcelona, Spain [2] CIBERDEM (Spanish Biomedical Research Centre in 
      Diabetes and Associated Metabolic Disorders), Instituto de Salud Carlos III, 
      Madrid, Spain.
FAU - Bassols, Judit
AU  - Bassols J
AD  - 1] Pediatrics Research Group, Girona Institute for Biomedical Research, Girona, 
      Spain [2] Department of Pediatrics, Dr Josep Trueta Hospital, Girona, Spain.
FAU - Lopez-Bermejo, Abel
AU  - Lopez-Bermejo A
AD  - 1] Pediatrics Research Group, Girona Institute for Biomedical Research, Girona, 
      Spain [2] Department of Pediatrics, Dr Josep Trueta Hospital, Girona, Spain [3] 
      TransLab Research Group, Department of Medical Sciences, Faculty of Medicine, 
      University of Girona, Girona, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140306
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Eye Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (SFRP5 protein, human)
RN  - 0 (WNT5A protein, human)
RN  - 0 (Wnt Proteins)
RN  - 0 (Wnt-5a Protein)
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Adiponectin/metabolism
MH  - Adipose Tissue/*metabolism
MH  - Alanine Transaminase/metabolism
MH  - Biomarkers/*metabolism
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Carotid Intima-Media Thickness
MH  - Child
MH  - Eye Proteins/*blood/genetics
MH  - Homeostasis/*genetics/physiology
MH  - Humans
MH  - Insulin Resistance/*genetics
MH  - Logistic Models
MH  - Membrane Proteins/*blood/genetics
MH  - Proto-Oncogene Proteins/*blood/genetics
MH  - Spain
MH  - Ultrasonography
MH  - Wnt Proteins/*blood/genetics
MH  - Wnt-5a Protein
MH  - gamma-Glutamyltransferase/metabolism
EDAT- 2014/03/08 06:00
MHDA- 2015/02/03 06:00
CRDT- 2014/03/08 06:00
PHST- 2013/08/07 00:00 [received]
PHST- 2013/11/18 00:00 [accepted]
PHST- 2014/03/08 06:00 [entrez]
PHST- 2014/03/08 06:00 [pubmed]
PHST- 2015/02/03 06:00 [medline]
AID - pr201429 [pii]
AID - 10.1038/pr.2014.29 [doi]
PST - ppublish
SO  - Pediatr Res. 2014 Jun;75(6):793-7. doi: 10.1038/pr.2014.29. Epub 2014 Mar 6.