PMID- 24603486
OWN - NLM
STAT- MEDLINE
DCOM- 20150212
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 6
DP  - 2014
TI  - HLA polymorphism and susceptibility to end-stage renal disease in Cantonese 
      patients awaiting kidney transplantation.
PG  - e90869
LID - 10.1371/journal.pone.0090869 [doi]
LID - e90869
AB  - BACKGROUND: End-Stage Renal Disease (ESRD) is a worldwide public health problem. 
      Currently, many genome-wide association studies have suggested a potential 
      association between human leukocyte antigen (HLA) and ESRD by uncovering a causal 
      relationship between HLA and glomerulonephritis. However, previous studies, which 
      investigated the HLA polymorphism and its association with ESRD, were performed 
      with the modest data sets and thus might be limited. On the other hand, few 
      researches were conducted to tackle the Chinese population with ESRD. Therefore, 
      this study aims to detect the susceptibilities of HLA polymorphism to ESRD within 
      the Cantonese community, a representative southern population of China. METHODS: 
      From the same region, 4541 ESRD patients who were waiting for kidney 
      transplantation and 3744 healthy volunteer bone marrow donors (controls) were 
      randomly chosen for this study. Polymerase chain reaction-sequence specific 
      primer method was used to analyze the HLA polymorphisms (including HLA-A, HLA-B 
      and HLA-DRB1 loci) in both ESRD patients and controls. The frequencies of alleles 
      at these loci and haplotypes were compared between ESRD patients and controls. 
      RESULTS: A total of 88 distinct HLA alleles and 1361 HLA A-B-DRB1 haplotypes were 
      detected. The frequencies of five alleles, HLA-A*24, HLA-B*55, HLA-B*54, 
      HLA-B*40(60), HLA-DRB1*04, and one haplotype (HLA-A*11-B*27-DRB1*04) in ESRD 
      patients are significantly higher than those in the controls, respectively. 
      CONCLUSIONS: Five HLA alleles and one haplotype at the HLA-A, HLA-B and HLA-DRB1 
      loci appear to be associated with ESRD within the Cantonese population.
FAU - Cao, Qiong
AU  - Cao Q
AD  - Division of Tissue Typing Center, Nanfang Hospital, Southern Medical University, 
      Guangdong, Guangzhou, China.
FAU - Xie, Di
AU  - Xie D
AD  - Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangdong, 
      Guangzhou, China.
FAU - Liu, Jiangmei
AU  - Liu J
AD  - Department of Biostatistics, School of Public Health and Tropical Medicine, 
      Southern Medical University, Guangdong, Guangzhou, China.
FAU - Zou, Hongyan
AU  - Zou H
AD  - HLA High-Resolution Confirmatory Typing Laboratory, Shenzhen Blood Center, 
      Shenzhen, China.
FAU - Zhang, Yinze
AU  - Zhang Y
AD  - HLA High-Resolution Confirmatory Typing Laboratory, Shenzhen Blood Center, 
      Shenzhen, China.
FAU - Zhang, Hong
AU  - Zhang H
AD  - Division of Tissue Typing Center, Nanfang Hospital, Southern Medical University, 
      Guangdong, Guangzhou, China.
FAU - Zhang, Zhimei
AU  - Zhang Z
AD  - Division of Tissue Typing Center, Nanfang Hospital, Southern Medical University, 
      Guangdong, Guangzhou, China.
FAU - Xue, Hao
AU  - Xue H
AD  - Division of Tissue Typing Center, Nanfang Hospital, Southern Medical University, 
      Guangdong, Guangzhou, China.
FAU - Zhou, Jiyuan
AU  - Zhou J
AD  - Department of Biostatistics, School of Public Health and Tropical Medicine, 
      Southern Medical University, Guangdong, Guangzhou, China.
FAU - Chen, Pingyan
AU  - Chen P
AD  - Department of Biostatistics, School of Public Health and Tropical Medicine, 
      Southern Medical University, Guangdong, Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140306
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Child
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Kidney Failure, Chronic/*genetics/surgery
MH  - Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Young Adult
PMC - PMC3946267
COIS- Competing Interests: All the authors declared no competing interests.
EDAT- 2014/03/08 06:00
MHDA- 2015/02/13 06:00
PMCR- 2014/03/06
CRDT- 2014/03/08 06:00
PHST- 2013/08/30 00:00 [received]
PHST- 2014/02/06 00:00 [accepted]
PHST- 2014/03/08 06:00 [entrez]
PHST- 2014/03/08 06:00 [pubmed]
PHST- 2015/02/13 06:00 [medline]
PHST- 2014/03/06 00:00 [pmc-release]
AID - PONE-D-13-35677 [pii]
AID - 10.1371/journal.pone.0090869 [doi]
PST - epublish
SO  - PLoS One. 2014 Mar 6;9(6):e90869. doi: 10.1371/journal.pone.0090869. eCollection 
      2014.