PMID- 24603592
OWN - NLM
STAT- MEDLINE
DCOM- 20150130
LR  - 20211124
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 3
DP  - 2014
TI  - Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone 
      acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model.
PG  - e91303
LID - 10.1371/journal.pone.0091303 [doi]
LID - e91303
AB  - The management of neuropathic pain is still a major challenge because of its 
      unresponsiveness to most common treatments. Curcumin has been reported to play an 
      active role in the treatment of various neurological disorders, such as 
      neuropathic pain. Curcumin has long been recognized as a p300/CREB-binding 
      protein (CBP) inhibitor of histone acetyltransferase (HAT) activity. However, 
      this mechanism has never been investigated for the treatment of neuropathic pain 
      with curcumin. The aim of the present study was to investigate the 
      anti-nociceptive role of curcumin in the chronic constriction injury (CCI) rat 
      model of neuropathic pain. Furthermore, with this model we investigated the 
      effect of curcumin on P300/CBP HAT activity-regulated release of the 
      pro-nociceptive molecules, brain-derived neurotrophic factor (BDNF) and 
      cyclooxygenase-2 (Cox-2). Treatment with 40 and 60 mg/kg body weight curcumin for 
      7 consecutive days significantly attenuated CCI-induced thermal hyperalgesia and 
      mechanical allodynia, whereas 20 mg/kg curcumin showed no significant analgesic 
      effect. Chromatin immunoprecipitation analysis revealed that curcumin 
      dose-dependently reduced the recruitment of p300/CBP and acetyl-Histone 
      H3/acetyl-Histone H4 to the promoter of BDNF and Cox-2 genes. A similar 
      dose-dependent decrease of BDNF and Cox-2 in the spinal cord was also observed 
      after curcumin treatment. These results indicated that curcumin exerted a 
      therapeutic role in neuropathic pain by down-regulating p300/CBP HAT 
      activity-mediated gene expression of BDNF and Cox-2.
FAU - Zhu, Xiaoyan
AU  - Zhu X
AD  - Department of Anesthesiology, Xiangya Hospital of Central South University, 
      Changsha, China.
FAU - Li, Qian
AU  - Li Q
AD  - Department of Anesthesiology, Xiangya Hospital of Central South University, 
      Changsha, China.
FAU - Chang, Ruimin
AU  - Chang R
AD  - Liver Cancer Laboratory, Xiangya Hospital of Central South University, Changsha, 
      China.
FAU - Yang, Dong
AU  - Yang D
AD  - Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Song, Zongbing
AU  - Song Z
AD  - Department of Anesthesiology, Xiangya Hospital of Central South University, 
      Changsha, China.
FAU - Guo, Qulian
AU  - Guo Q
AD  - Department of Anesthesiology, Xiangya Hospital of Central South University, 
      Changsha, China.
FAU - Huang, Changsheng
AU  - Huang C
AD  - Department of Anesthesiology, Xiangya Hospital of Central South University, 
      Changsha, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140306
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Analgesics)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Histones)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 2.3.1.48 (p300-CBP Transcription Factors)
RN  - IT942ZTH98 (Curcumin)
RN  - K3Z4F929H6 (Lysine)
SB  - IM
MH  - Acetylation/drug effects
MH  - Analgesics/pharmacology/therapeutic use
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Curcumin/*pharmacology/therapeutic use
MH  - Cyclooxygenase 2/*genetics/metabolism
MH  - Disease Models, Animal
MH  - Enzyme Inhibitors/pharmacology/therapeutic use
MH  - Gene Expression Regulation, Enzymologic/*drug effects
MH  - Histones/chemistry/metabolism
MH  - Lysine/metabolism
MH  - Male
MH  - Neuralgia/*drug therapy/*genetics/metabolism/physiopathology
MH  - Nociception/drug effects
MH  - Promoter Regions, Genetic/drug effects/genetics
MH  - Protein Transport/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord/drug effects/metabolism
MH  - p300-CBP Transcription Factors/*antagonists & inhibitors/metabolism
PMC - PMC3946321
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/03/08 06:00
MHDA- 2015/01/31 06:00
PMCR- 2014/03/06
CRDT- 2014/03/08 06:00
PHST- 2013/11/12 00:00 [received]
PHST- 2014/02/10 00:00 [accepted]
PHST- 2014/03/08 06:00 [entrez]
PHST- 2014/03/08 06:00 [pubmed]
PHST- 2015/01/31 06:00 [medline]
PHST- 2014/03/06 00:00 [pmc-release]
AID - PONE-D-13-47409 [pii]
AID - 10.1371/journal.pone.0091303 [doi]
PST - epublish
SO  - PLoS One. 2014 Mar 6;9(3):e91303. doi: 10.1371/journal.pone.0091303. eCollection 
      2014.