PMID- 24603739
OWN - NLM
STAT- MEDLINE
DCOM- 20140512
LR  - 20140307
IS  - 1678-9849 (Electronic)
IS  - 0037-8682 (Linking)
VI  - 47
IP  - 1
DP  - 2014 Jan-Feb
TI  - Paracoccidioidomycosis in a western Brazilian Amazon State: 
      clinical-epidemiologic profile and spatial distribution of the disease.
PG  - 63-8
LID - S0037-86822014000100063 [pii]
LID - 10.1590/0037-8682-0225-2013 [doi]
AB  - INTRODUCTION: Paracoccidioidomycosis (PCM) is a systemic infection caused by the 
      fungus Paracoccidioides brasiliensis. PCM is considered one of the most important 
      systemic mycoses in Latin America. METHODS: This is a clinical, epidemiological, 
      retrospective, quantitative study of PCM cases in patients attending the National 
      Health Service in the State of Rondonia in 1997-2012. The examined variables 
      included sex, age group, year of diagnosis, education level, profession, place of 
      residence, diagnostic test, prior treatment, medication used, comorbidities and 
      case progress. RESULTS: During the study period, 2,163 PCM cases were registered 
      in Rondonia, and the mean annual incidence was 9.4/100,000 people. The 
      municipalities with the highest rates were located in the southeastern region of 
      Rondonia, and the towns of Pimenteiras do Oeste and Espigao do Oeste had the 
      highest rates in the state, which were 39.1/100,000 and 37.4/100,000 people, 
      respectively. Among all cases, 90.2% and 9.8% were observed in men and women, 
      respectively, and most cases (58.2%) were observed in patients aged between 40 
      and 59 years. Itraconazole was used to treat 91.6% (1,771) of cases, followed by 
      sulfamethoxazole in combination with trimethoprim (4.4% [85] of cases). One 
      hundred thirty-one (6%) patients died. CONCLUSIONS: The State of Rondonia has a 
      high incidence of PCM, and the municipalities in the southeastern region of the 
      state were found to have the highest incidence rates of this disease. Our 
      findings suggest that Rondonia is the state in the northern region with the 
      highest mortality rate for PCM.
FAU - Vieira, Gabriel de Deus
AU  - Vieira Gde D
AD  - Departamento de Medicina, Faculdade Sao Lucas, Porto VelhoRO, Departamento de 
      Medicina, Faculdade Sao Lucas, Porto Velho, RO.
FAU - Alves, Thaianne da Cunha
AU  - Alves Tda C
AD  - Departamento de Medicina, Faculdade Sao Lucas, Porto VelhoRO, Departamento de 
      Medicina, Faculdade Sao Lucas, Porto Velho, RO.
FAU - Lima, Sonia Maria Dias de
AU  - Lima SM
AD  - Departamento de Medicina, Faculdade Sao Lucas, Porto VelhoRO, Departamento de 
      Medicina, Faculdade Sao Lucas, Porto Velho, RO.
FAU - Camargo, Luis Marcelo Aranha
AU  - Camargo LM
AD  - Departamento de Medicina, Faculdade Sao Lucas, Porto VelhoRO, Departamento de 
      Medicina, Faculdade Sao Lucas, Porto Velho, RO.
FAU - Sousa, Camila Maciel de
AU  - Sousa CM
AD  - Departamento de Medicina, Faculdade Sao Lucas, Porto VelhoRO, Departamento de 
      Medicina, Faculdade Sao Lucas, Porto Velho, RO.
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Rev Soc Bras Med Trop
JT  - Revista da Sociedade Brasileira de Medicina Tropical
JID - 7507456
RN  - 0 (Antifungal Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Antifungal Agents/therapeutic use
MH  - Brazil/epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Paracoccidioidomycosis/drug therapy/*epidemiology/mortality
MH  - Retrospective Studies
MH  - Socioeconomic Factors
MH  - Space-Time Clustering
MH  - Topography, Medical
MH  - Young Adult
EDAT- 2014/03/08 06:00
MHDA- 2014/05/13 06:00
CRDT- 2014/03/08 06:00
PHST- 2013/10/29 00:00 [received]
PHST- 2014/01/30 00:00 [accepted]
PHST- 2014/03/08 06:00 [entrez]
PHST- 2014/03/08 06:00 [pubmed]
PHST- 2014/05/13 06:00 [medline]
AID - S0037-86822014000100063 [pii]
AID - 10.1590/0037-8682-0225-2013 [doi]
PST - ppublish
SO  - Rev Soc Bras Med Trop. 2014 Jan-Feb;47(1):63-8. doi: 10.1590/0037-8682-0225-2013.