PMID- 24603804
OWN - NLM
STAT- MEDLINE
DCOM- 20141113
LR  - 20140319
IS  - 1791-2423 (Electronic)
IS  - 1019-6439 (Linking)
VI  - 44
IP  - 5
DP  - 2014 May
TI  - MicroRNA-126 modulates the tumor microenvironment by targeting 
      calmodulin-regulated spectrin-associated protein 1 (Camsap1).
PG  - 1678-84
LID - 10.3892/ijo.2014.2321 [doi]
AB  - Plasma miRNAs have been reported as biomarkers for various diseases. In this 
      study, we investigated whether plasma concentrations of miR-126 may be useful as 
      biomarkers for laryngeal squamous cell carcinoma (LSCC). We examined the function 
      and mechanism of miR-126 in LSCC by using cell biology and molecular pathology 
      techniques such as western blotting, quantitative PCR, IHC and IF. The expression 
      of Camsap1 mRNA and protein is higher in cancer tissues compared to that in 
      normal tissues. Both miR-126 and Camsap1 were related with the prognosis of LSCC 
      patients. We found that miR-126 was able to inhibit LSCC partly by suppressing 
      Camsap1 expression. In addition, Camsap1 expression induced microtubule formation 
      and aggregation. This mechanism possibly explains why loss of miR-126 is 
      frequently associated with tumor metastasis.
FAU - Sun, Xin
AU  - Sun X
AD  - Department of Otorhinolarynology, Shengjing Hospital, China Medical University, 
      Shenyang 110004, P.R. China.
FAU - Wang, Zhi-Ming
AU  - Wang ZM
AD  - Department of Stomatology, Shengjing Hospital, China Medical University, Shenyang 
      110004, P.R. China.
FAU - Song, Yan
AU  - Song Y
AD  - Department of Otorhinolarynology, Shengjing Hospital, China Medical University, 
      Shenyang 110004, P.R. China.
FAU - Tai, Xu-Hui
AU  - Tai XH
AD  - Department of Otorhinolarynology, Chinese PLA 463 Hospital, P.R. China.
FAU - Ji, Wen-Yue
AU  - Ji WY
AD  - Department of Otorhinolarynology, Shengjing Hospital, China Medical University, 
      Shenyang 110004, P.R. China.
FAU - Gu, Hui
AU  - Gu H
AD  - Department of Central Laboratory, Shengjing Hospital, China Medical University, 
      Shenyang 110004, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140305
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
RN  - 0 (CAMSAP1 protein, human)
RN  - 0 (MIRN126 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Microtubule-Associated Proteins)
SB  - IM
MH  - Animals
MH  - Carcinoma, Squamous Cell/blood/*pathology
MH  - Cell Line, Tumor
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/blood/*pathology
MH  - Male
MH  - Mice
MH  - Mice, Nude
MH  - MicroRNAs/*blood/*genetics
MH  - Microtubule-Associated Proteins/*genetics/*metabolism
MH  - Microtubules/metabolism
MH  - Middle Aged
MH  - Neoplasm Metastasis/genetics/pathology
MH  - Neoplasms, Experimental
MH  - Phylogeny
MH  - Prognosis
MH  - Tumor Microenvironment
EDAT- 2014/03/08 06:00
MHDA- 2014/11/14 06:00
CRDT- 2014/03/08 06:00
PHST- 2013/12/29 00:00 [received]
PHST- 2014/02/14 00:00 [accepted]
PHST- 2014/03/08 06:00 [entrez]
PHST- 2014/03/08 06:00 [pubmed]
PHST- 2014/11/14 06:00 [medline]
AID - 10.3892/ijo.2014.2321 [doi]
PST - ppublish
SO  - Int J Oncol. 2014 May;44(5):1678-84. doi: 10.3892/ijo.2014.2321. Epub 2014 Mar 5.