PMID- 24604309
OWN - NLM
STAT- MEDLINE
DCOM- 20140930
LR  - 20191210
IS  - 1678-2674 (Electronic)
IS  - 0102-8650 (Linking)
VI  - 29
IP  - 2
DP  - 2014 Feb
TI  - Severe autogenously fecal peritonitis in Wistar rats with permanent bilateral 
      carotid occlusion. Response to intra peritoneal moxifloxacin combined with 
      dexamethasone.
PG  - 76-81
LID - S0102-86502014000200076 [pii]
LID - 10.1590/S0102-86502014000200001 [doi]
AB  - PURPOSE: To evaluate the treatment outcome of severe peritonitis in rats 
      submitted to permanent bilateral carotid occlusion (PBCO). METHODS: Sixteen 
      Wistar rats (mean age of 8.5 months) with PBCO underwent autogenously fecal 
      peritonitis, and were treated with moxifloxacin combined with dexamethasone, and 
      followed-up for 45 days. Ten rats (mean age five months) without PBCO were used 
      as a control group. The variables were expressed by their mean and standard error 
      of the mean (SEM). p<0.05 was used for rejecting the null hypothesis. The study 
      was approved by the Ethics Committee. RESULTS: There was a significant increase 
      (p=0.0002) in the mortality and morbidity in older rats that underwent PBCO 
      (study group). However, even among the survival rats presenting with severe 
      residual abscesses both in the abdomen and thorax cavities, they present an 
      almost normal life. CONCLUSIONS: The treatment of severe autogenously fecal 
      peritonitis with intraperitoneal moxifloxacin combined with dexamethasone was 
      very effective in young rats without permanent bilateral carotid occlusion. The 
      treatment reached reasonable results in older rats with PBCO, even considering 
      residual abscesses on abdomen and thorax. Older age was the greater risk factor 
      for the outcome of the treatment of severe peritonitis. Sepsis remains a 
      challenging situation, especially in elderly.
FAU - Melo, Maria Cecilia Santos Cavalcanti
AU  - Melo MC
AD  - Campina Grande Faculty of Medicine, Department of Ophthalmology, Campina 
      GrandePB, Brazil, IFellow PhD degree, Postgraduate Program in Surgery, Health 
      Sciences Center, Federal University of Pernambuco (UFPE). Assistant Professor, 
      Department of Ophthalmology, Campina Grande Faculty of Medicine (FCM), Campina 
      Grande-PB, Brazil. Acquisition and interpretation of data, manuscript writing.
FAU - Gadelha, Diego Nery Benevides
AU  - Gadelha DN
AD  - FCM, Department of Ophthalmology, Campina GrandePB, Brazil, IIFellow PhD degree, 
      Postgraduate Program in Surgery, Health Sciences Center, UFPE, Recife-PE. 
      Associate Professor, Department of Ophthalmology, FCM, Campina Grande-PB, Brazil. 
      Manuscript writing, critical revision.
FAU - Oliveira, Tharcia Kiara Beserra
AU  - Oliveira TK
AD  - Campina Grande University, Campina GrandePB, Brazil, IIIFellow Master Degree in 
      Agricultural Engineering, Federal Campina Grande University (UFCG)-PB, Campina 
      Grande-PB, Brazil. Acquisition and interpretation of data.
FAU - Brandt, Carlos Teixeira
AU  - Brandt CT
AD  - UFPE, Campina GrandePB, Brazil, IVPhD, Head Professor, Scientific Methodology and 
      Pediatric Surgery, UFPE, Recife-PE. Coordinator, FCM, Campina Grande-PB, Brazil. 
      Interpretation of data, English version. final revision.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Acta Cir Bras
JT  - Acta cirurgica brasileira
JID - 9103983
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Drug Combinations)
RN  - 0 (Fluoroquinolones)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - U188XYD42P (Moxifloxacin)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - *Carotid Artery, Common
MH  - Dexamethasone/*therapeutic use
MH  - Drug Combinations
MH  - Feces
MH  - Fluoroquinolones/*therapeutic use
MH  - Models, Animal
MH  - Moxifloxacin
MH  - Peritonitis/*drug therapy/pathology
MH  - Rats, Wistar
MH  - Reproducibility of Results
MH  - Time Factors
MH  - Tissue Adhesions
MH  - Treatment Outcome
EDAT- 2014/03/08 06:00
MHDA- 2014/10/01 06:00
CRDT- 2014/03/08 06:00
PHST- 2013/10/17 00:00 [received]
PHST- 2014/01/20 00:00 [accepted]
PHST- 2014/03/08 06:00 [entrez]
PHST- 2014/03/08 06:00 [pubmed]
PHST- 2014/10/01 06:00 [medline]
AID - S0102-86502014000200076 [pii]
AID - 10.1590/S0102-86502014000200001 [doi]
PST - ppublish
SO  - Acta Cir Bras. 2014 Feb;29(2):76-81. doi: 10.1590/S0102-86502014000200001.