PMID- 24604632
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20211021
IS  - 1995-8218 (Electronic)
IS  - 1673-7067 (Print)
IS  - 1995-8218 (Linking)
VI  - 30
IP  - 2
DP  - 2014 Apr
TI  - MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse 
      model of Alzheimer's disease.
PG  - 191-7
LID - 10.1007/s12264-013-1419-7 [doi]
AB  - MicroRNA alterations have been reported in patients with Alzheimer's disease (AD) 
      and AD mouse models. We now report that miR-206 is upregulated in the hippocampal 
      tissue, cerebrospinal fluid, and plasma of embryonic APP/PS1 transgenic mice. The 
      increased miR-206 downregulates the expression of brain-derived neurotrophic 
      factor (BDNF). BDNF is neuroprotective against cell death after various insults, 
      but in embryonic and newborn APP/PS1 mice it is decreased. Thus, a specific 
      microRNA alteration may contribute to AD pathology by downregulating BDNF.
FAU - Tian, Ning
AU  - Tian N
AD  - Beijing Obstetrics & Gynecology Hospital, Capital Medical University, Beijing, 
      100026, China.
FAU - Cao, Zeyuan
AU  - Cao Z
FAU - Zhang, Yan
AU  - Zhang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140306
PL  - Singapore
TA  - Neurosci Bull
JT  - Neuroscience bulletin
JID - 101256850
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (MicroRNAs)
RN  - 0 (Mirn206 microRNA, mouse)
SB  - IM
MH  - Alzheimer Disease/*metabolism
MH  - Animals
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Gene Expression Regulation/*physiology
MH  - Hippocampus/metabolism
MH  - Mice
MH  - Mice, Transgenic
MH  - MicroRNAs/*metabolism
MH  - Real-Time Polymerase Chain Reaction
PMC - PMC5562663
EDAT- 2014/03/08 06:00
MHDA- 2014/12/15 06:00
PMCR- 2015/04/01
CRDT- 2014/03/08 06:00
PHST- 2013/08/29 00:00 [received]
PHST- 2013/11/06 00:00 [accepted]
PHST- 2014/03/08 06:00 [entrez]
PHST- 2014/03/08 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2015/04/01 00:00 [pmc-release]
AID - 1419 [pii]
AID - 10.1007/s12264-013-1419-7 [doi]
PST - ppublish
SO  - Neurosci Bull. 2014 Apr;30(2):191-7. doi: 10.1007/s12264-013-1419-7. Epub 2014 
      Mar 6.