PMID- 24604664
OWN - NLM
STAT- MEDLINE
DCOM- 20151001
LR  - 20220129
IS  - 1522-2594 (Electronic)
IS  - 0740-3194 (Print)
IS  - 0740-3194 (Linking)
VI  - 73
IP  - 2
DP  - 2015 Feb
TI  - Dynamic inversion time for improved 3D late gadolinium enhancement imaging in 
      patients with atrial fibrillation.
PG  - 646-54
LID - 10.1002/mrm.25190 [doi]
AB  - PURPOSE: High resolution three-dimensional (3D) late gadolinium enhancement (LGE) 
      imaging is performed with single R-wave gating to minimize lengthy acquisition 
      durations. In patients with atrial fibrillation (AF), heart rate variability 
      results in variable magnetization recovery between sequence repeats, and image 
      quality is often poor. In this study, we implemented and tested a dynamic 
      inversion time (dynamic-TI) scheme designed to reduce sequence sensitivity to 
      heart rate variations. METHODS: An inversion-prepared 3D segmented gradient echo 
      sequence was modified so that the TI varied automatically from beat-to-beat 
      (dynamic-TI) based on the time since the last sequence repeat. 3D LGE 
      acquisitions were performed in 17 patients prior to radio frequency ablation of 
      persistent AF both with and without dynamic-TI. Qualitative image quality scores, 
      blood signal-to-ghosting ratios (SGRs). and blood-myocardium contrast-to-ghosting 
      ratios (CGRs) were compared. RESULTS: Image quality scores were higher with 
      dynamic-TI than without dynamic-TI (2.2 +/- 0.9 vs. 1.8 +/- 1.1, P = 0.008), as were 
      blood-myocardium CGRs (13.8 +/- 7.6 vs. 8.3 +/- 6.1, P = 0.003) and blood SGRs (19.6 
      +/- 8.5 vs. 13.1 +/- 8.0, P = 0.003). CONCLUSION: The dynamic-TI algorithm improves 
      image quality of 3D LGE imaging in this difficult patient population by reducing 
      the sequence sensitivity to RR interval variations
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Keegan, Jennifer
AU  - Keegan J
AD  - Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, 
      London, United Kingdom.
FAU - Gatehouse, Peter D
AU  - Gatehouse PD
FAU - Haldar, Shouvik
AU  - Haldar S
FAU - Wage, Ricardo
AU  - Wage R
FAU - Babu-Narayan, Sonya V
AU  - Babu-Narayan SV
FAU - Firmin, David N
AU  - Firmin DN
LA  - eng
GR  - Wellcome Trust/United Kingdom
GR  - 093953/Wellcome Trust/United Kingdom
GR  - FS/11/38/28864/BHF_/British Heart Foundation/United Kingdom
GR  - WT093953MA/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140306
PL  - United States
TA  - Magn Reson Med
JT  - Magnetic resonance in medicine
JID - 8505245
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Aged
MH  - *Algorithms
MH  - Atrial Fibrillation/*pathology
MH  - Contrast Media/administration & dosage
MH  - Female
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Imaging, Three-Dimensional/*methods
MH  - Male
MH  - Middle Aged
MH  - *Organometallic Compounds/administration & dosage
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
PMC - PMC4562369
MID - EMS64793
OID - NLM: EMS64793
OTO - NOTNLM
OT  - 3D
OT  - arrhythmia
OT  - late gadolinium enhancement imaging
EDAT- 2014/03/08 06:00
MHDA- 2015/10/02 06:00
PMCR- 2015/09/08
CRDT- 2014/03/08 06:00
PHST- 2013/07/24 00:00 [received]
PHST- 2014/01/09 00:00 [revised]
PHST- 2014/02/03 00:00 [accepted]
PHST- 2014/03/08 06:00 [entrez]
PHST- 2014/03/08 06:00 [pubmed]
PHST- 2015/10/02 06:00 [medline]
PHST- 2015/09/08 00:00 [pmc-release]
AID - 10.1002/mrm.25190 [doi]
PST - ppublish
SO  - Magn Reson Med. 2015 Feb;73(2):646-54. doi: 10.1002/mrm.25190. Epub 2014 Mar 6.