PMID- 24605080
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140307
LR  - 20211021
IS  - 1598-2629 (Print)
IS  - 2092-6685 (Electronic)
IS  - 1598-2629 (Linking)
VI  - 14
IP  - 1
DP  - 2014 Feb
TI  - Ursodeoxycholic Acid ameliorates pain severity and cartilage degeneration in 
      monosodium iodoacetate-induced osteoarthritis in rats.
PG  - 45-53
LID - 10.4110/in.2014.14.1.45 [doi]
AB  - Osteoarthritis (OA) is a degenerative joint disease characterized by a 
      progressive loss of cartilage. And, increased oxidative stress plays a relevant 
      role in the pathogenesis of OA. Ursodeoxycholic acid (UDCA) is a used drug for 
      liver diseases known for its free radical-scavenging property. The objectives of 
      this study were to investigate the in vivo effects of UDCA on pain severity and 
      cartilage degeneration using an experimental OA model and to explore its mode of 
      actions. OA was induced in rats by intra-articular injection of monosodium 
      iodoacetate (MIA) to the knee. Oral administration UDCA was initiated on the day 
      of MIA injection. Limb nociception was assessed by measuring the paw withdrawal 
      latency and threshold. Samples were analyzed macroscopically and histologically. 
      Immunohistochemistry was used to investigate the expression of interleukin-1beta 
      (IL-1beta), IL-6, nitrotyrosine and inducible nitric oxide synthase (iNOS) in knee 
      joints. UDCA showed an antinociceptive property and attenuated cartilage 
      degeneration. OA rats given oral UDCA significantly exhibited a decreased number 
      of osteoclasts in subchondral bone legion compared with the vehicle-treated OA 
      group. UDCA reduced the expression of IL-1beta, IL-6, nitrotyrosine and iNOS in 
      articular cartilage. UDCA treatment significantly attenuated the mRNA expression 
      of matrix metalloproteinase-3 (MMP-3), -13, and ADAMTS5 in IL-1beta-stimulated human 
      OA chondrocytes. These results show the inhibitory effects of UDCA on pain 
      production and cartilage degeneration in experimentally induced OA. The 
      chondroprotective properties of UDCA were achieved by suppressing oxidative 
      damage and inhibiting catabolic factors that are implicated in the pathogenesis 
      of cartilage damage in OA.
FAU - Moon, Su-Jin
AU  - Moon SJ
AD  - Division of Rheumatology, Department of Internal Medicine, College of Medicine, 
      The Catholic University of Korea, Seoul 137-040, Korea.
FAU - Jeong, Jeong-Hee
AU  - Jeong JH
AD  - The Rheumatism Research Center, Catholic Research Institute of Medical Science, 
      The Catholic University of Korea, Seoul 137-040, Korea.
FAU - Jhun, Joo Yeon
AU  - Jhun JY
AD  - The Rheumatism Research Center, Catholic Research Institute of Medical Science, 
      The Catholic University of Korea, Seoul 137-040, Korea.
FAU - Yang, Eun Ji
AU  - Yang EJ
AD  - The Rheumatism Research Center, Catholic Research Institute of Medical Science, 
      The Catholic University of Korea, Seoul 137-040, Korea.
FAU - Min, Jun-Ki
AU  - Min JK
AD  - Division of Rheumatology, Department of Internal Medicine, College of Medicine, 
      The Catholic University of Korea, Seoul 137-040, Korea.
FAU - Choi, Jong Young
AU  - Choi JY
AD  - Division of Hepatology, Department of Internal Medicine, College of Medicine, The 
      Catholic University of Korea, Seoul 137-040, Korea.
FAU - Cho, Mi-La
AU  - Cho ML
AD  - The Rheumatism Research Center, Catholic Research Institute of Medical Science, 
      The Catholic University of Korea, Seoul 137-040, Korea.
LA  - eng
PT  - Journal Article
DEP - 20140221
PL  - Korea (South)
TA  - Immune Netw
JT  - Immune network
JID - 101137270
PMC - PMC3942507
OTO - NOTNLM
OT  - Monosodium iodoacetate (MIA)
OT  - Osteoarthritis
OT  - Oxidative stress
OT  - Ursodeoxycholic acid (UDCA)
COIS- The authors have no financial conflict of interest.
EDAT- 2014/03/08 06:00
MHDA- 2014/03/08 06:01
PMCR- 2014/02/01
CRDT- 2014/03/08 06:00
PHST- 2013/12/02 00:00 [received]
PHST- 2014/02/10 00:00 [revised]
PHST- 2014/02/20 00:00 [accepted]
PHST- 2014/03/08 06:00 [entrez]
PHST- 2014/03/08 06:00 [pubmed]
PHST- 2014/03/08 06:01 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - 10.4110/in.2014.14.1.45 [doi]
PST - ppublish
SO  - Immune Netw. 2014 Feb;14(1):45-53. doi: 10.4110/in.2014.14.1.45. Epub 2014 Feb 
      21.