PMID- 24605128 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20140307 LR - 20211021 IS - 1738-3684 (Print) IS - 1976-3026 (Electronic) IS - 1738-3684 (Linking) VI - 11 IP - 1 DP - 2014 Jan TI - Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs. PG - 84-8 LID - 10.4306/pi.2014.11.1.84 [doi] AB - OBJECTIVE: It is important to predict a response to an antidepressant in early time after starting the antidepressant. We previously reported that serum brain-derived neurotrophic factor (BDNF) levels in responders to treatment with antidepressants were increased, whereas, those in nonresponders were not. Therefore, we hypothesized that the changes in serum levels of BDNF from baseline (T0) to 4 weeks (T4) after treatment with selective serotonin reuptake inhibitors (SSRIs) predict the response to the treatment at 8 weeks (T8) in depressed patients. To confirm the hypothesis, we measured serum BDNF at T0, T4, and T8 during the treatment with SSRIs (paroxetine, sertraline, and fluvoxamine). METHODS: One hundred fifty patients (M/F; 51/99, age; 50.4+/-15.1 years) met major depressive disorder (MDD) using by DSM-IV-TR enrolled in the present study. We measured serum BDNF concentrations at T0, T4, and T8 in patients with MDD treated with SSRIs. RESULTS: The changes in serum BDNF, age, sex, dose of SSRIs, and HAMD-17 score did not predict the response to SSRIs at T8. CONCLUSION: These results suggest that the changes in serum BDNF levels from T0 to T4 could not predict the subsequent responses to SSRIs at T8. FAU - Yoshimura, Reiji AU - Yoshimura R AD - Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan. FAU - Kishi, Taro AU - Kishi T AD - Zucker Hillside Hospital, Glen Oaks, New York, USA. ; Fujita Health University School of Medicine, Toyoake, Japan. FAU - Hori, Hikaru AU - Hori H AD - Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan. FAU - Katsuki, Asuka AU - Katsuki A AD - Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan. FAU - Sugita-Ikenouchi, Atsuko AU - Sugita-Ikenouchi A AD - Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan. FAU - Umene-Nakano, Wakako AU - Umene-Nakano W AD - Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan. FAU - Atake, Kiyokazu AU - Atake K AD - Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan. FAU - Iwata, Nakao AU - Iwata N AD - Fujita Health University School of Medicine, Toyoake, Japan. FAU - Nakamura, Jun AU - Nakamura J AD - Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan. LA - eng PT - Journal Article DEP - 20140121 PL - Korea (South) TA - Psychiatry Investig JT - Psychiatry investigation JID - 101242994 PMC - PMC3942556 OTO - NOTNLM OT - Brain-derived neurotrophic factor OT - Depression OT - Response OT - Selective serotonin reuptake inhibitor OT - Serum EDAT- 2014/03/08 06:00 MHDA- 2014/03/08 06:01 PMCR- 2014/01/01 CRDT- 2014/03/08 06:00 PHST- 2013/01/18 00:00 [received] PHST- 2013/04/15 00:00 [revised] PHST- 2013/06/14 00:00 [accepted] PHST- 2014/03/08 06:00 [entrez] PHST- 2014/03/08 06:00 [pubmed] PHST- 2014/03/08 06:01 [medline] PHST- 2014/01/01 00:00 [pmc-release] AID - 10.4306/pi.2014.11.1.84 [doi] PST - ppublish SO - Psychiatry Investig. 2014 Jan;11(1):84-8. doi: 10.4306/pi.2014.11.1.84. Epub 2014 Jan 21.