PMID- 24606089
OWN - NLM
STAT- MEDLINE
DCOM- 20140808
LR  - 20171116
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 99
IP  - 6
DP  - 2014 Jun
TI  - The metabolically healthy but obese phenotype is associated with lower plasma 
      levels of persistent organic pollutants as compared to the metabolically abnormal 
      obese phenotype.
PG  - E1061-6
LID - 10.1210/jc.2013-3935 [doi]
AB  - CONTEXT: Although obesity is strongly linked to insulin resistance and type 2 
      diabetes, a subset of obese individuals termed metabolically healthy but obese 
      (MHO) appears relatively protected from the development of cardiometabolic 
      complications. The origins of this metabolically healthy phenotype remain 
      unclear. Recently, persistent organic pollutants (POPs) have emerged as potential 
      endocrine disruptors. OBJECTIVE: The aim of this study was to test the hypothesis 
      that the MHO phenotype presents lower circulating levels of POPs as compared to 
      the metabolically abnormal obese (MAO) phenotype. DESIGN, SETTING, AND PATIENTS: 
      We conducted a cross-sectional study of 76 nondiabetic obese (body mass index >/=30 
      kg/m(2)) postmenopausal women. MAIN OUTCOME MEASURES: Plasma concentrations of 21 
      POPs as well as cardiometabolic risk factors were analyzed. RESULTS: For similar 
      age, body mass index, and fat mass index, MHO women (n = 40) showed higher 
      insulin sensitivity levels and a more favorable cardiometabolic profile than MAO 
      women (n = 36), as evidenced by a 2-fold increase in glucose disposal rates 
      measured by the hyperinsulinemic-euglycemic clamp (P = .001). Among 18 detectable 
      pollutants measured, MAO women had higher plasma concentrations of 12 POPs (fold 
      increase, 1.4-2.9; P < .001-.036). Logistic regression analyses showed that the 
      prevalence of the MAO phenotype was significantly associated with higher levels 
      of total dioxin- and non-dioxin-like polychlorinated biphenyls (odds ratio, 4.7; 
      95% confidence interval, 1.8-12.5; P = .002), as well as trans-nonachlor (odds 
      ratio, 6.1; 95% CI, 2.2-16.4; P < .001). CONCLUSION: Our study demonstrates that 
      the metabolically healthy and abnormal phenotypes have distinct plasma POP 
      profiles.
FAU - Gauthier, Marie-Soleil
AU  - Gauthier MS
AD  - Institut de Recherches Cliniques de Montreal (M.-S.G., R.R.-L.), Montreal, 
      Quebec, H2W 1R7, Canada; Montreal Diabetes Research Centre at the Centre de 
      Recherche du Centre Hospitalier de l'Universite de Montreal (CRCHUM) (M.-S.G., 
      R.R.-L.) Montreal, Quebec, H1W 4A4, Canada; The Nutrition Department (R.R.-L.), 
      Universite de Montreal; the Endocrinology Division (R.R.-L.), Montreal University 
      Hospital, Montreal, Quebec, Canada H2W 1T8; School of Human Kinetics, Faculty of 
      Health Sciences, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada; Institut 
      de Recherche de l'Hopital Montfort (D.P.), Ottawa, Ontario, K1K 0T2, Canada; 
      Department of Kinanthropology (A.K.), Universite du Quebec a Montreal, Montreal, 
      Quebec, Canada H3C 3P8; MTM Research Center (D.G., B.v.B.), School of Science and 
      Technology, Orebro University, SE-701 82 Orebro, Sweden; and Department of 
      Biology (J.R.), University of Bergen, N-5006 Bergen, Norway.
FAU - Rabasa-Lhoret, Remi
AU  - Rabasa-Lhoret R
FAU - Prud'homme, Denis
AU  - Prud'homme D
FAU - Karelis, Antony D
AU  - Karelis AD
FAU - Geng, Dawei
AU  - Geng D
FAU - van Bavel, Bert
AU  - van Bavel B
FAU - Ruzzin, Jerome
AU  - Ruzzin J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140225
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
SB  - IM
CIN - J Clin Endocrinol Metab. 2014 Jun;99(6):1993-4. PMID: 24893136
MH  - Aged
MH  - *Body Mass Index
MH  - Cardiovascular Diseases/epidemiology/etiology
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Health
MH  - Humans
MH  - Metabolic Syndrome/epidemiology/etiology
MH  - Middle Aged
MH  - Obesity/blood/complications/epidemiology/*metabolism
MH  - Organic Chemicals/*blood
MH  - Overweight/blood/complications/epidemiology
MH  - Phenotype
MH  - Risk Factors
EDAT- 2014/03/13 06:00
MHDA- 2014/08/13 06:00
CRDT- 2014/03/11 06:00
PHST- 2014/03/11 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2014/08/13 06:00 [medline]
AID - 10.1210/jc.2013-3935 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2014 Jun;99(6):E1061-6. doi: 10.1210/jc.2013-3935. Epub 
      2014 Feb 25.