PMID- 24607259
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20161020
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 17
IP  - 9
DP  - 2014 Sep
TI  - Effects of brief pulse and ultrabrief pulse electroconvulsive stimulation on 
      rodent brain and behaviour in the corticosterone model of depression.
PG  - 1477-86
LID - 10.1017/S1461145714000200 [doi]
AB  - Brief pulse electroconvulsive therapy (BP ECT; pulse width 0.5-1.5 ms) is the 
      most effective treatment available for severe depression. However, its use is 
      associated with side-effects. The stimulus in ultrabrief pulse ECT (UBP ECT; 
      pulse width 0.25-0.3 ms) is more physiological and has been reported to be 
      associated with less cognitive side-effects, but its antidepressant effectiveness 
      is not yet well established. Using electroconvulsive stimulation (ECS), the 
      animal model of ECT, we previously reported UBP ECS to be significantly less 
      effective than well-established BP ECS in eliciting behavioural, molecular and 
      cellular antidepressant-related effects in naive rats. We have now compared the 
      effects of BP and UBP ECS in an animal model of depression related to exogenous 
      supplementation with the stress-induced glucocorticoid hormone, corticosterone. 
      Corticosterone administration resulted in an increase in immobility time in the 
      forced swim test (FST) (p < 0.01) and decreases in the expression of 
      brain-derived neurotrophic factor (BDNF) (p < 0.05) and glial fibrillary acidic 
      protein (GFAP) (p < 0.001) in the hippocampus and frontal cortex. There was no 
      significant difference in the duration or type of seizure induced by BP (0.5 ms) 
      or UBP (0.3 ms) ECS. UBP ECS proved to be as effective as BP ECS at inducing a 
      behavioural antidepressant response in the FST with a significant decrease (p < 
      0.001) in immobility seen following administration of ECS. Both forms of ECS also 
      induced significant increases in BDNF protein (p < 0.01) expression in the 
      hippocampus. BP ECS (p < 0.05) but not UBP ECS induced a significant increase in 
      GFAP levels in the hippocampus and frontal cortex. Overall, UBP ECS effectively 
      induced antidepressant-related behavioural and molecular responses in the 
      corticosterone supplementation model, providing the first preclinical data on the 
      potential role of this form of ECS to treat a depression phenotype related to 
      elevated corticosterone.
FAU - O'Donovan, Sinead
AU  - O'Donovan S
AD  - Trinity College Institute of Neuroscience,Trinity College Dublin, Dublin 
      2,Ireland.
FAU - Dalton, Victoria
AU  - Dalton V
AD  - Trinity College Institute of Neuroscience,Trinity College Dublin, Dublin 
      2,Ireland.
FAU - Harkin, Andrew
AU  - Harkin A
AD  - School of Pharmacy & Pharmaceutical Sciences & Trinity College Institute of 
      Neuroscience,Trinity College Dublin, Dublin 2,Ireland.
FAU - McLoughlin, Declan M
AU  - McLoughlin DM
AD  - St. Patrick's University Hospital & Trinity College Institute of 
      Neuroscience,Trinity College Dublin,Ireland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140310
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (RNA, Messenger)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenal Glands/drug effects
MH  - Analysis of Variance
MH  - Animals
MH  - Anti-Inflammatory Agents/*toxicity
MH  - Body Weight/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Corticosterone/*toxicity
MH  - Depression/*chemically induced/*therapy
MH  - Disease Models, Animal
MH  - Eating/drug effects
MH  - Electroconvulsive Therapy/*methods
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Glial Fibrillary Acidic Protein/genetics/metabolism
MH  - Male
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Swimming/psychology
EDAT- 2014/03/13 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/03/11 06:00
PHST- 2014/03/11 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - S1461145714000200 [pii]
AID - 10.1017/S1461145714000200 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2014 Sep;17(9):1477-86. doi: 
      10.1017/S1461145714000200. Epub 2014 Mar 10.