PMID- 24607879
OWN - NLM
STAT- MEDLINE
DCOM- 20150624
LR  - 20161125
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Linking)
VI  - 21
IP  - 11
DP  - 2014 Nov
TI  - Association between neurotrophin 4 and long-chain polyunsaturated fatty acid 
      levels in mid-trimester amniotic fluid.
PG  - 1395-400
LID - 10.1177/1933719114526474 [doi]
AB  - The omega-3 long-chain polyunsaturated fatty acid (LCPUFA) docosahexaenoic acid 
      (DHA) and the omega-6 LCPUFA arachidonic acid (AA) are essential nervous system 
      components that increase in concentration throughout gestation. The 
      neurotrophins, brain-derived neurotrophic factor (BDNF), nerve growth factor 
      (NGF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4) are small basic peptides 
      crucial for fetal brain development. The DHA supplementation during pregnancy has 
      been suggested to enhance neural development. We evaluated whether amniotic fluid 
      DHA and AA concentrations correlated with intra-amniotic neurotrophin levels. 
      Amniotic fluid, obtained at 15 to 19 weeks gestation from 62 women, was tested 
      for BDNF, NGF, NT3, and NT4 by enzyme-linked immunosorbent assay. Concentrations 
      of DHA and AA, and saturated and monounsaturated fatty acids, were determined by 
      gas chromatography. Associations were analyzed by the Spearman rank correlation 
      test. Median levels of AA and DHA were 2.3% and 1.3% of the total intra-amniotic 
      fatty acids, respectively. Median neurotrophin levels (pg/mL) were 36.7 for NT3, 
      26.8 for BDNF, 5.2 for NT4, and 0.8 for NGF. Intra-amniotic NT4 and BDNF levels 
      were correlated (P = .0016), while NT3 and NGF levels were unrelated to each 
      other or to BDNF or NT4. Only NT4 was positively correlated with amniotic fluid 
      DHA (P < .0001) and AA (P = .0003) concentrations. There were no associations 
      between DHA, AA, or any neurotrophin and maternal age, gestational age at time of 
      amniocentesis, amniocentesis indication, parity, or gestational age at delivery. 
      Elevations in intra-amniotic NT4 with increasing levels of DHA and AA suggest 
      that these LCPUFAs may specifically influence the extent of NT4-mediated fetal 
      brain neurogenesis.
CI  - (c) The Author(s) 2014.
FAU - Benn, Kiesha
AU  - Benn K
AD  - Department of Obstetrics and Gynecology, Division of Immunology and Infectious 
      Diseases, Weill Cornell Medical College, New York, NY, USA Department of 
      Obstetrics and Gynecology, New York Hospital Queens, Queens, New York, NY, USA.
FAU - Passos, Mariana
AU  - Passos M
AD  - Department of Obstetrics and Gynecology, Division of Immunology and Infectious 
      Diseases, Weill Cornell Medical College, New York, NY, USA.
FAU - Jayaram, Aswathi
AU  - Jayaram A
AD  - Department of Obstetrics and Gynecology, Division of Immunology and Infectious 
      Diseases, Weill Cornell Medical College, New York, NY, USA.
FAU - Harris, Mary
AU  - Harris M
AD  - Department of Food Science and Human Nutrition, Colorado State University, Fort 
      Collins, CO, USA.
FAU - Bongiovanni, Ann Marie
AU  - Bongiovanni AM
AD  - Department of Obstetrics and Gynecology, Division of Immunology and Infectious 
      Diseases, Weill Cornell Medical College, New York, NY, USA.
FAU - Skupski, Daniel
AU  - Skupski D
AD  - Department of Obstetrics and Gynecology, New York Hospital Queens, Queens, New 
      York, NY, USA.
FAU - Witkin, Steven S
AU  - Witkin SS
AD  - Department of Obstetrics and Gynecology, Division of Immunology and Infectious 
      Diseases, Weill Cornell Medical College, New York, NY, USA 
      switkin@med.cornell.edu.
LA  - eng
PT  - Journal Article
DEP - 20140307
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
RN  - 0 (Nerve Growth Factors)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - 27YG812J1I (Arachidonic Acid)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Adult
MH  - Amniotic Fluid/*chemistry
MH  - Arachidonic Acid/*analysis
MH  - Chromatography, Gas
MH  - Docosahexaenoic Acids/*analysis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Nerve Growth Factors/*analysis
MH  - Pregnancy
MH  - Pregnancy Trimester, Second
MH  - Up-Regulation
OTO - NOTNLM
OT  - amniotic fluid
OT  - arachidonic acid
OT  - docosahexaenoic acid
OT  - neurogenesis
OT  - neurotrophins
EDAT- 2014/03/13 06:00
MHDA- 2015/06/25 06:00
CRDT- 2014/03/11 06:00
PHST- 2014/03/11 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2015/06/25 06:00 [medline]
AID - 1933719114526474 [pii]
AID - 10.1177/1933719114526474 [doi]
PST - ppublish
SO  - Reprod Sci. 2014 Nov;21(11):1395-400. doi: 10.1177/1933719114526474. Epub 2014 
      Mar 7.