PMID- 24609106
OWN - NLM
STAT- MEDLINE
DCOM- 20150212
LR  - 20220311
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 6
DP  - 2014
TI  - External error monitoring in subclinical obsessive-compulsive subjects: 
      electrophysiological evidence from a Gambling Task.
PG  - e90874
LID - 10.1371/journal.pone.0090874 [doi]
LID - e90874
AB  - BACKGROUND: Feedback-related negativity (FRN) is believed to be an important 
      electrophysiology index of "external" negative feedback processing. Previous 
      studies on FRN in obsessive-compulsive (OC) individuals are scarce and 
      controversial. In these studies, anxiety symptoms were not evaluated in detail. 
      However, OC disorders have a number of radical differences from anxiety 
      disorders. It is necessary to study FRN and its neuroanatomical correlates in OC 
      individuals without anxious symptoms. METHODS: A total of 628 undergraduate 
      students completed an OC questionnaire. We chose 14 students who scored in the 
      upper 10% and 14 students who scored in the lowest 10% without anxiety symptoms 
      as a subclinical OC group (SOC) and a low obsessive-compulsive group (LOC). The 
      students all performed the revised Iowa Gambling Task. We used the event-related 
      potentials (ERP) and standardized low-resolution brain electromagnetic tomography 
      (sLORETA) to track external negative feedback processing and its substrate in the 
      brain. RESULTS: Our study revealed poorer decision-making ability and greater FRN 
      amplitudes in SOC subjects compared with LOC controls. The SOC subjects displayed 
      anterior prefrontal cortex (aPFC) hyperactivation during the loss feedback 
      condition. Specifically, we found an intercorrelation of current source density 
      during the loss condition between the dorsal anterior cingulate cortex (dACC) and 
      aPFC in the LOC subjects but not in the SOC group. CONCLUSIONS: Our results 
      support the notion that overactive external feedback error processing may reflect 
      a candidate endophenotype of OC. We also provide important information on the 
      dysfunction in the interaction between aPFC and dACC in populations with OC. 
      Nevertheless, the findings support that OC may be distinguished from other 
      anxiety disorders using a new electrophysiology perspective.
FAU - Zhu, Chunyan
AU  - Zhu C
AD  - Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui 
      Medical University, Hefei, China.
FAU - Yu, Fengqiong
AU  - Yu F
AD  - Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui 
      Medical University, Hefei, China.
FAU - Ye, Rong
AU  - Ye R
AD  - Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui 
      Medical University, Hefei, China.
FAU - Chen, Xingui
AU  - Chen X
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, China.
FAU - Dong, Yi
AU  - Dong Y
AD  - Anhui Mental Health Center, Hefei, China.
FAU - Li, Dan
AU  - Li D
AD  - Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui 
      Medical University, Hefei, China.
FAU - Zhang, Long
AU  - Zhang L
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, China.
FAU - Li, Dandan
AU  - Li D
AD  - Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui 
      Medical University, Hefei, China.
FAU - Wang, Kai
AU  - Wang K
AD  - Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui 
      Medical University, Hefei, China; Department of Neurology, The First Affiliated 
      Hospital of Anhui Medical University, Hefei, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140307
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Anxiety/physiopathology/psychology
MH  - Evoked Potentials
MH  - Feedback, Psychological
MH  - Female
MH  - Gambling/*physiopathology/psychology
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
MH  - Obsessive-Compulsive Disorder/*physiopathology/psychology
MH  - Prefrontal Cortex/physiopathology
MH  - Young Adult
PMC - PMC3946632
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/03/13 06:00
MHDA- 2015/02/13 06:00
PMCR- 2014/03/07
CRDT- 2014/03/11 06:00
PHST- 2013/10/15 00:00 [received]
PHST- 2014/02/06 00:00 [accepted]
PHST- 2014/03/11 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2015/02/13 06:00 [medline]
PHST- 2014/03/07 00:00 [pmc-release]
AID - PONE-D-13-42144 [pii]
AID - 10.1371/journal.pone.0090874 [doi]
PST - epublish
SO  - PLoS One. 2014 Mar 7;9(6):e90874. doi: 10.1371/journal.pone.0090874. eCollection 
      2014.