PMID- 24609111
OWN - NLM
STAT- MEDLINE
DCOM- 20150221
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 3
DP  - 2014
TI  - Abnormal default-mode network homogeneity in first-episode, drug-naive major 
      depressive disorder.
PG  - e91102
LID - 10.1371/journal.pone.0091102 [doi]
LID - e91102
AB  - BACKGROUND: Default mode network (DMN) is one of the most commonly recognized 
      resting-state networks in major depressive disorder (MDD). However, the 
      homogeneity of this network in MDD is poorly understood. As such, this study was 
      conducted to determine whether or not an abnormal network homogeneity (NH) of DMN 
      is observed in patients with first-episode and drug-naive MDD. METHODS: 
      Twenty-four first-episode drug-naive patients with MDD and twenty-four healthy 
      control subjects participated in the study. NH and independent component analysis 
      (ICA) methods were used to analyze data. RESULTS: Depressed patients exhibited a 
      significantly increased NH in the left dorsal medial prefrontal cortex (MPFC) and 
      decreased NH in the right inferior temporal gyrus (ITG) compared with the healthy 
      control subjects. Receiver operating characteristic curves (ROC) were analyzed 
      and results revealed that the NH values of MPFC and ITG could be applied as 
      candidate markers with relatively high sensitivity and specificity to distinguish 
      patients from healthy control subjects. No correlation was observed between the 
      NH values of the two regions and clinical variables. CONCLUSIONS: Our findings 
      suggested that an abnormal DMN homogeneity could be observed in MDD, which 
      highlight the importance of the DMN in the pathophysiology of MDD.
FAU - Guo, Wenbin
AU  - Guo W
AD  - Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, 
      Nanning, Guangxi, China.
FAU - Liu, Feng
AU  - Liu F
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu, Sichuan, China.
FAU - Zhang, Jian
AU  - Zhang J
AD  - Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, 
      Nanning, Guangxi, China.
FAU - Zhang, Zhikun
AU  - Zhang Z
AD  - Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, 
      Nanning, Guangxi, China.
FAU - Yu, Liuyu
AU  - Yu L
AD  - Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, 
      Nanning, Guangxi, China.
FAU - Liu, Jianrong
AU  - Liu J
AD  - Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, 
      Nanning, Guangxi, China.
FAU - Chen, Huafu
AU  - Chen H
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu, Sichuan, China.
FAU - Xiao, Changqing
AU  - Xiao C
AD  - Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, 
      Nanning, Guangxi, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140307
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Demography
MH  - Depressive Disorder, Major/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Nerve Net/*physiopathology
MH  - ROC Curve
PMC - PMC3946684
COIS- Competing Interests: Co-author Huafu Chen is a PLOS ONE Editorial Board member. 
      This does not alter our adherence to PLOS ONE Editorial policies and criteria.
EDAT- 2014/03/13 06:00
MHDA- 2015/02/24 06:00
PMCR- 2014/03/07
CRDT- 2014/03/11 06:00
PHST- 2013/11/06 00:00 [received]
PHST- 2014/02/07 00:00 [accepted]
PHST- 2014/03/11 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
PHST- 2014/03/07 00:00 [pmc-release]
AID - PONE-D-13-46650 [pii]
AID - 10.1371/journal.pone.0091102 [doi]
PST - epublish
SO  - PLoS One. 2014 Mar 7;9(3):e91102. doi: 10.1371/journal.pone.0091102. eCollection 
      2014.