PMID- 24610234
OWN - NLM
STAT- MEDLINE
DCOM- 20150212
LR  - 20220310
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 122
IP  - 6
DP  - 2014 Jun
TI  - The human early-life exposome (HELIX): project rationale and design.
PG  - 535-44
LID - 10.1289/ehp.1307204 [doi]
AB  - BACKGROUND: Developmental periods in early life may be particularly vulnerable to 
      impacts of environmental exposures. Human research on this topic has generally 
      focused on single exposure-health effect relationships. The "exposome" concept 
      encompasses the totality of exposures from conception onward, complementing the 
      genome. OBJECTIVES: The Human Early-Life Exposome (HELIX) project is a new 
      collaborative research project that aims to implement novel exposure assessment 
      and biomarker methods to characterize early-life exposure to multiple 
      environmental factors and associate these with omics biomarkers and child health 
      outcomes, thus characterizing the "early-life exposome." Here we describe the 
      general design of the project. METHODS: In six existing birth cohort studies in 
      Europe, HELIX will estimate prenatal and postnatal exposure to a broad range of 
      chemical and physical exposures. Exposure models will be developed for the full 
      cohorts totaling 32,000 mother-child pairs, and biomarkers will be measured in a 
      subset of 1,200 mother-child pairs. Nested repeat-sampling panel studies (n = 
      150) will collect data on biomarker variability, use smartphones to assess 
      mobility and physical activity, and perform personal exposure monitoring. Omics 
      techniques will determine molecular profiles (metabolome, proteome, 
      transcriptome, epigenome) associated with exposures. Statistical methods for 
      multiple exposures will provide exposure-response estimates for fetal and child 
      growth, obesity, neurodevelopment, and respiratory outcomes. A health impact 
      assessment exercise will evaluate risks and benefits of combined exposures. 
      CONCLUSIONS: HELIX is one of the first attempts to describe the early-life 
      exposome of European populations and unravel its relation to omics markers and 
      health in childhood. As proof of concept, it will form an important first step 
      toward the life-course exposome.
FAU - Vrijheid, Martine
AU  - Vrijheid M
AD  - Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
FAU - Slama, Remy
AU  - Slama R
FAU - Robinson, Oliver
AU  - Robinson O
FAU - Chatzi, Leda
AU  - Chatzi L
FAU - Coen, Muireann
AU  - Coen M
FAU - van den Hazel, Peter
AU  - van den Hazel P
FAU - Thomsen, Cathrine
AU  - Thomsen C
FAU - Wright, John
AU  - Wright J
FAU - Athersuch, Toby J
AU  - Athersuch TJ
FAU - Avellana, Narcis
AU  - Avellana N
FAU - Basagana, Xavier
AU  - Basagana X
FAU - Brochot, Celine
AU  - Brochot C
FAU - Bucchini, Luca
AU  - Bucchini L
FAU - Bustamante, Mariona
AU  - Bustamante M
FAU - Carracedo, Angel
AU  - Carracedo A
FAU - Casas, Maribel
AU  - Casas M
FAU - Estivill, Xavier
AU  - Estivill X
FAU - Fairley, Lesley
AU  - Fairley L
FAU - van Gent, Diana
AU  - van Gent D
FAU - Gonzalez, Juan R
AU  - Gonzalez JR
FAU - Granum, Berit
AU  - Granum B
FAU - Grazuleviciene, Regina
AU  - Grazuleviciene R
FAU - Gutzkow, Kristine B
AU  - Gutzkow KB
FAU - Julvez, Jordi
AU  - Julvez J
FAU - Keun, Hector C
AU  - Keun HC
FAU - Kogevinas, Manolis
AU  - Kogevinas M
FAU - McEachan, Rosemary R C
AU  - McEachan RR
FAU - Meltzer, Helle Margrete
AU  - Meltzer HM
FAU - Sabido, Eduard
AU  - Sabido E
FAU - Schwarze, Per E
AU  - Schwarze PE
FAU - Siroux, Valerie
AU  - Siroux V
FAU - Sunyer, Jordi
AU  - Sunyer J
FAU - Want, Elizabeth J
AU  - Want EJ
FAU - Zeman, Florence
AU  - Zeman F
FAU - Nieuwenhuijsen, Mark J
AU  - Nieuwenhuijsen MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140307
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Biomarkers)
RN  - 0 (Proteome)
SB  - IM
CIN - Environ Health Perspect. 2014 Jun;122(6):A169. PMID: 24892972
MH  - Biomarkers
MH  - Child
MH  - Child Development
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Environmental Exposure/*adverse effects/*analysis/statistics & numerical data
MH  - Epigenomics
MH  - Europe
MH  - Female
MH  - Fetal Development
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Maternal Exposure/adverse effects/statistics & numerical data
MH  - Metabolome
MH  - Obesity
MH  - Pregnancy
MH  - Proteome
MH  - Transcriptome
PMC - PMC4048258
COIS- N.A. is employed by Sensing & Control Systems SL, Igualada, Spain. L.B. is 
      employed by Hylobates Consulting S.R.L., Rome, Italy. The authors declare they 
      have no actual or potential competing financial interests.
EDAT- 2014/03/13 06:00
MHDA- 2015/02/13 06:00
PMCR- 2014/06/01
CRDT- 2014/03/11 06:00
PHST- 2013/06/11 00:00 [received]
PHST- 2014/03/06 00:00 [accepted]
PHST- 2014/03/11 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2015/02/13 06:00 [medline]
PHST- 2014/06/01 00:00 [pmc-release]
AID - ehp.1307204 [pii]
AID - 10.1289/ehp.1307204 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2014 Jun;122(6):535-44. doi: 10.1289/ehp.1307204. Epub 
      2014 Mar 7.