PMID- 24610619
OWN - NLM
STAT- MEDLINE
DCOM- 20150402
LR  - 20220408
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 18
IP  - 4
DP  - 2014
TI  - Study of co-transplantation of SPIO labeled bone marrow stromal stem cells and 
      Schwann cells for treating traumatic brain injury in rats and in vivo tracing of 
      magnetically labeled cells by MRI.
PG  - 520-5
LID - 6862 [pii]
AB  - AIM: The aims of this study are to investigate the effects of co-transplantation 
      Bone Marrow Stromal Stem Cells (BMSCs) and Schwann Cells (SCs) in treating rat 
      traumatic brain injury (TBI), the migration of BMSCs in the brain, and whether 
      co-transplantation treatment is superior to single transplantation. MATERIALS AND 
      METHODS: Superparamagnetic iron oxide (SPIO) labeled BMSCs and SCs were 
      transplanted and co-transplanted into the rats with TBI. The neurological 
      functions of the rats were evaluated by the NSS (Neurological Severity Score) at 
      day 3, 7, 14, and 30. Moreover, 7.0T MRI (Magnetic Resonance Imaging) scan was 
      conducted in order to observe the migration of the labeled BMSCs. RESULTS: MRI 
      scan showed that when SPIO labeled BMSCs were injected into the brain, T2WI 
      (weighted image) showed low signals and these low signals migrated toward the 
      lesion. The speed of migration was faster in the co-transplantation group than in 
      the single transplantation group. NSS results showed that the prognosis was 
      better in the co-transplantation group than in the single transplantation group 
      at day 14 after injection. CONCLUSIONS: The co-transplantation of BMSCs and SCs 
      showed faster cell migration and better prognosis in rat TBI.
FAU - Xu, H-S
AU  - Xu HS
AD  - Department of Neurosurgery, Central Hospital of Xuzhou, Xuzhou, Jiangsu, China. 
      xhs51@126.com.
FAU - Ma, C
AU  - Ma C
FAU - Cao, L
AU  - Cao L
FAU - Wang, J-J
AU  - Wang JJ
FAU - Fan, X-X
AU  - Fan XX
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Contrast Media)
RN  - 0 (Dextrans)
RN  - 0 (Magnetite Nanoparticles)
RN  - G6N3J05W84 (ferumoxides)
SB  - IM
MH  - Animals
MH  - Brain/pathology/physiopathology/*surgery
MH  - Brain Injuries/diagnosis/pathology/physiopathology/*surgery
MH  - Cell Movement
MH  - Cell Tracking/*methods
MH  - Cells, Cultured
MH  - Contrast Media
MH  - *Dextrans
MH  - Disease Models, Animal
MH  - *Magnetic Resonance Imaging
MH  - *Magnetite Nanoparticles
MH  - Male
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Neurologic Examination
MH  - Rats, Sprague-Dawley
MH  - Recovery of Function
MH  - Schwann Cells/pathology/*transplantation
MH  - Time Factors
EDAT- 2014/03/13 06:00
MHDA- 2015/04/04 06:00
CRDT- 2014/03/11 06:00
PHST- 2014/03/11 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2015/04/04 06:00 [medline]
AID - 6862 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2014;18(4):520-5.