PMID- 24611143
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141216
LR  - 20211021
IS  - 2228-5806 (Print)
IS  - 2228-5814 (Electronic)
IS  - 2228-5806 (Linking)
VI  - 16
IP  - 3
DP  - 2014 Fall
TI  - A Rare De novo Complex Chromosomal Rearrangement (CCR) Involving Four Chromosomes 
      in An Oligo-asthenosperm Infertile Man.
PG  - 377-82
AB  - Complex chromosomal rearrangements (CCRs) are rare events involving more than two 
      chromosomes and over two breakpoints. They are usually associated with 
      infertility or sub fertility in male carriers. Here we report a novel case of a 
      CCR in a 30-year-old oligoasthenosperm man with a history of varicocelectomy, 
      normal testes size and normal endocrinology profile referred for chromosome 
      analysis to the Genetics unit of Royan Reproductive Biomedicine Research Center. 
      Chromosomal analysis was performed using peripheral blood lymphocyte cultures and 
      analyzed by GTG banding. Additional tests such as C-banding and multicolor 
      fluorescence in situ hybridization (FISH) procedure for each of the involved 
      chromosomes were performed to determine the patterns of the segregations. Y 
      chromosome microdeletions in the azoospermia factor (AZF) region were analyzed 
      with multiplex polymerase chain reaction. To identify the history and origin of 
      this CCR, all the family members were analyzed. No micro deletion in Y chromosome 
      was detected. The same de novo reciprocal exchange was also found in his 
      monozygous twin brother. The other siblings and parents were normal. CCRs are 
      associated with male infertility as a result of spermatogenic disruption due to 
      complex meiotic configurations and the production of chromosomally abnormal 
      sperms. These chromosomal rearrangements might have an influence on decreasing 
      the number of sperms.
FAU - Asia, Saba
AU  - Asia S
AD  - Department of Genetics at Reproductive Biomedicine Research Center, Royan 
      Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
FAU - Vaziri Nasab, Hamed
AU  - Vaziri Nasab H
AD  - Department of Genetics at Reproductive Biomedicine Research Center, Royan 
      Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
FAU - Sabbaghian, Marjan
AU  - Sabbaghian M
AD  - Department of Andrology at Reproductive Biomedicine Research Center, Royan 
      Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
FAU - Kalantari, Hamid
AU  - Kalantari H
AD  - Department of Genetics at Reproductive Biomedicine Research Center, Royan 
      Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
FAU - Zari Moradi, Shabnam
AU  - Zari Moradi S
AD  - Department of Genetics at Reproductive Biomedicine Research Center, Royan 
      Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
FAU - Gourabi, Hamid
AU  - Gourabi H
AD  - Department of Genetics at Reproductive Biomedicine Research Center, Royan 
      Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
FAU - Mohseni Meybodi, Anahita
AU  - Mohseni Meybodi A
AD  - Department of Genetics at Reproductive Biomedicine Research Center, Royan 
      Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20141004
PL  - Iran
TA  - Cell J
JT  - Cell journal
JID - 101566618
PMC - PMC4204197
OTO - NOTNLM
OT  - Complex Chromosomal Rearrangement (CCR)
OT  - FISH
OT  - Infertility
OT  - Karyotype
EDAT- 2014/03/13 06:00
MHDA- 2014/03/13 06:01
PMCR- 2014/09/01
CRDT- 2014/03/11 06:00
PHST- 2013/07/08 00:00 [received]
PHST- 2013/08/17 00:00 [accepted]
PHST- 2014/03/11 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2014/03/13 06:01 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - CellJ.2014.16(3).15 [pii]
PST - ppublish
SO  - Cell J. 2014 Fall;16(3):377-82. Epub 2014 Oct 4.