PMID- 24611333
OWN - NLM
STAT- MEDLINE
DCOM- 20140331
LR  - 20140311
IS  - 0350-6134 (Print)
IS  - 0350-6134 (Linking)
VI  - 37
IP  - 4
DP  - 2013 Dec
TI  - CTLA-4 +49 and TNF-alpha-308 gene polymorphisms in celiac patients with exocrine 
      pancreatic insufficiency.
PG  - 1191-4
AB  - Celiac disease (CD) is a life-long gluten sensitive autoimmune disease of the 
      small intestine affecting genetically susceptible individuals. Human leukocyte 
      antigen (HLA) genotype contributes to the genetic risk for CD, but "non-HLA" 
      genes also play a role. Clinical presentation could be classical, but majority of 
      patients present with non-classical, atypical signs and symptoms. Endocrine 
      and/or exocrine pancreatic insufficiency (EXPI) is common in celiac patients. The 
      aim of our study was to assess EXPI among our CD patients by measurement of 
      faecal pancreatic elastase (FE1) and to find potential association of CTLA-4 +49 
      and TNF-alpha-308 gene polymorphism and EXPI. Eighty three patients entered the 
      study. Tissue transglutaminase antibodies (anti-TTG), faecal elastase-1 (FE1) 
      assays and genotyping for the CTLA-4 +49A/G and TNF-alpha308 were performed. Of 
      83 patients with CD EXPI had 13 (15.6 %). There was no statistically significant 
      difference in frequency of polymorphisms for both genes (CTL-4 +49 i 
      TNF-alpha-308) in the group with and without EXPI. In conclusion, EXPI is common 
      in symptomatic CD patients, but further genetic studies with larger number of 
      patients are needed.
FAU - Licul, Vanja
AU  - Licul V
AD  - University of Rijeka, University Hospital Center Rijeka, Division of Internal 
      Medicine, Department of Gastroenterology, Rijeka, Croatia. vlicul2@yahoo.com
FAU - Cizmarevic, Nada Starcevic
AU  - Cizmarevic NS
AD  - University of Rijeka, School of Medicine, Department of Biology and Medical 
      Genetics, Rijeka, Croatia.
FAU - Ristic, Smiljana
AU  - Ristic S
AD  - University of Rijeka, School of Medicine, Department of Biology and Medical 
      Genetics, Rijeka, Croatia.
FAU - Mikolasevic, Ivana
AU  - Mikolasevic I
AD  - University of Rijeka, University Hospital Center Rijeka, Division of Internal 
      Medicine, Rijeka, Croatia.
FAU - Mijandrusic, Brankica Sincic
AU  - Mijandrusic BS
AD  - University of Rijeka, University Hospital Center Rijeka, Division of Internal 
      Medicine, Department of Gastroenterology, Rijeka, Croatia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Croatia
TA  - Coll Antropol
JT  - Collegium antropologicum
JID - 8003354
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (CTLA4 protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - CTLA-4 Antigen/*genetics
MH  - Celiac Disease/complications/*genetics
MH  - Exocrine Pancreatic Insufficiency/complications/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2014/03/13 06:00
MHDA- 2014/04/01 06:00
CRDT- 2014/03/12 06:00
PHST- 2014/03/12 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2014/04/01 06:00 [medline]
PST - ppublish
SO  - Coll Antropol. 2013 Dec;37(4):1191-4.