PMID- 24611611
OWN - NLM
STAT- MEDLINE
DCOM- 20150119
LR  - 20211021
IS  - 1476-5381 (Electronic)
IS  - 0007-1188 (Print)
IS  - 0007-1188 (Linking)
VI  - 171
IP  - 12
DP  - 2014 Jun
TI  - Impact of caloric restriction on myocardial ischaemia/reperfusion injury and new 
      therapeutic options to mimic its effects.
PG  - 2964-92
LID - 10.1111/bph.12650 [doi]
AB  - Caloric restriction (CR) is the most reliable intervention to extend lifespan and 
      prevent age-related disorders in various species from yeast to rodents. Short- 
      and long-term CR confers cardio protection against ischaemia/reperfusion injury 
      in young and even in aged rodents. A few human trials suggest that CR has the 
      potential to mediate improvement of cardiac or vascular function and induce 
      retardation of cardiac senescence also in humans. The underlying mechanisms are 
      diverse and have not yet been clearly defined. Among the known mediators for the 
      benefits of CR are NO, the AMP-activated PK, sirtuins and adiponectin. 
      Mitochondria, which play a central role in such complex processes within the cell 
      as apoptosis, ATP-production or oxidative stress, are centrally involved in many 
      aspects of CR-induced protection against ischaemic injury. Here, we discuss the 
      relevant literature regarding the protection against myocardial 
      ischaemia/reperfusion injury conferred by CR. Furthermore, we will discuss drug 
      targets to mimic CR and the possible role of calorie restriction in preserving 
      cardiovascular function in humans.
CI  - (c) 2014 The British Pharmacological Society.
FAU - Rohrbach, Susanne
AU  - Rohrbach S
AD  - Institute of Physiology, Justus Liebig University Giessen, Giessen, Germany.
FAU - Aslam, Muhammad
AU  - Aslam M
FAU - Niemann, Bernd
AU  - Niemann B
FAU - Schulz, Rainer
AU  - Schulz R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 0 (Cardiovascular Agents)
SB  - IM
MH  - Animals
MH  - *Caloric Restriction
MH  - Cardiovascular Agents/*pharmacology
MH  - Drug Design
MH  - Energy Metabolism
MH  - Humans
MH  - Mitochondria, Heart/metabolism
MH  - Myocardial Reperfusion Injury/metabolism/*prevention & control
MH  - Myocardium/*metabolism
MH  - Oxidative Stress
MH  - Signal Transduction
PMC - PMC4055200
OTO - NOTNLM
OT  - AMPK
OT  - CR mimetic
OT  - NO
OT  - ROS
OT  - mitobiogenesis
OT  - mitophagy
OT  - sirtuin
EDAT- 2014/03/13 06:00
MHDA- 2015/01/20 06:00
PMCR- 2015/06/01
CRDT- 2014/03/12 06:00
PHST- 2013/09/15 00:00 [received]
PHST- 2014/01/12 00:00 [revised]
PHST- 2014/02/10 00:00 [accepted]
PHST- 2014/03/12 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2015/01/20 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - 10.1111/bph.12650 [doi]
PST - ppublish
SO  - Br J Pharmacol. 2014 Jun;171(12):2964-92. doi: 10.1111/bph.12650.