PMID- 24612182
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20220409
IS  - 1440-1819 (Electronic)
IS  - 1323-1316 (Linking)
VI  - 68
IP  - 9
DP  - 2014 Sep
TI  - Heart rate variability in unmedicated patients with bipolar disorder in the manic 
      phase.
PG  - 674-82
LID - 10.1111/pcn.12178 [doi]
AB  - AIMS: Decreased heart rate variability (HRV) has been proposed in bipolar 
      disorder. To date, there has been no adequate study that has investigated resting 
      HRV in unmedicated patients with bipolar disorder in the manic state. METHODS: To 
      examine whether bipolar mania is associated with decreased HRV, 61 unmedicated 
      patients with bipolar mania and 183 healthy volunteers aged 20-65 years were 
      recruited for this case-control analysis. The Young Mania Rating Scale (YMRS), 
      Clinical Global Impression-Severity, Hamilton Depression Rating Scale (HAM-D), 
      and Hamilton Anxiety Rating Scale (HAM-A) were used for the clinical ratings. 
      Cardiac autonomic function was evaluated by measuring HRV parameters and the 
      frequency-domain indices of HRV were obtained. RESULTS: Patients with bipolar 
      mania exhibited significantly lower mean RR interval, variance, low-frequency 
      (LF)-HRV, and high-frequency (HF)-HRV but higher LF/HF compared to controls. 
      Decreased HRV (variance) was associated with the YMRS total scores. Both the YMRS 
      total scores and the Clinical Global Impression-Severity scores were positively 
      correlated with the LH/HF ratio and inversely correlated with the HF-HRV. There 
      was no significant correlation between the HAM-D/HAM-A scores and any HRV 
      parameter. CONCLUSIONS: Bipolar mania is associated with cardiac autonomic 
      dysregulation, highlighting the importance of assessing HRV in manic patients. 
      Further studies examining the influence of anti-manic psychotropic drugs on 
      cardiac autonomic regulation in bipolar mania are needed.
CI  - (c) 2014 The Authors. Psychiatry and Clinical Neurosciences (c) 2014 Japanese Society 
      of Psychiatry and Neurology.
FAU - Chang, Hsin-An
AU  - Chang HA
AD  - Department of Psychiatry, Tri-Service General Hospital, Taipei, Taiwan.
FAU - Chang, Chuan-Chia
AU  - Chang CC
FAU - Tzeng, Nian-Sheng
AU  - Tzeng NS
FAU - Kuo, Terry B J
AU  - Kuo TB
FAU - Lu, Ru-Band
AU  - Lu RB
FAU - Huang, San-Yuan
AU  - Huang SY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140413
PL  - Australia
TA  - Psychiatry Clin Neurosci
JT  - Psychiatry and clinical neurosciences
JID - 9513551
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bipolar Disorder/*physiopathology
MH  - Case-Control Studies
MH  - Female
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Activity/physiology
MH  - Psychiatric Status Rating Scales
MH  - Young Adult
OTO - NOTNLM
OT  - bipolar disorder
OT  - cardiac autonomic function
OT  - heart rate variability
OT  - mania
OT  - vagal control
EDAT- 2014/03/13 06:00
MHDA- 2015/05/12 06:00
CRDT- 2014/03/12 06:00
PHST- 2013/09/25 00:00 [received]
PHST- 2014/01/29 00:00 [revised]
PHST- 2014/02/18 00:00 [accepted]
PHST- 2014/03/12 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - 10.1111/pcn.12178 [doi]
PST - ppublish
SO  - Psychiatry Clin Neurosci. 2014 Sep;68(9):674-82. doi: 10.1111/pcn.12178. Epub 
      2014 Apr 13.