PMID- 24613044
OWN - NLM
STAT- MEDLINE
DCOM- 20150212
LR  - 20220317
IS  - 1444-2892 (Electronic)
IS  - 1443-9506 (Linking)
VI  - 23
IP  - 7
DP  - 2014 Jul
TI  - Pulmonary arterial hypertension and systemic sclerosis relation: a single centre 
      experience.
PG  - 667-73
LID - S1443-9506(14)00070-5 [pii]
LID - 10.1016/j.hlc.2014.02.002 [doi]
AB  - AIM: In systemic sclerosis (SSc), this single-centre study aimed to define the 
      frequency and association of pulmonary arterial hypertension (PAH), occurring 
      either alone in SSc-PAH or together with interstitial lung disease (ILD-PH). 
      MATERIAL-METHODS: SSc cases between the years 1990-2011 were reviewed, 
      retrospectively. Patients' clinical, laboratory findings, Modified Rodnan Skin 
      Score and Medsger score, 6-minute walk distance (6MWD), carbon monoxide diffusion 
      test (DLCO), echocardiography, thorax HRCT, and right heart catheterisation 
      findings were recorded. RESULTS: One hundred and forty-one cases (F/M:124/17, 
      diffuse cutaneous SSc (DcSSc)/limited cutaneous SSc (LcSSc): 84/57) were included 
      in the study with the mean age of 52.70+/-15.17 years and disease duration of 
      107.07+/-99.44 months. PaO(2), FEV1 and FVC were lower in DcSSc (p<0.05) as compared 
      to LcSSc, but DLCO and 6MWD did not differ significantly, between the two forms. 
      Ground glass opacity (64.7%) and interlobular septal thickening (58.8%) were the 
      most frequent findings on HRCT of such subjects. PAH was detected in 34 subjects 
      (24.1%). Seven of them had SSc associated PAH (SSc-PAH) and 27 ILD-PH. Both 
      frequencies were similar between DcSSc and LcSSc. Mean sPAP was higher in 
      SSc-PAH. CONCLUSION: PAH was observed in approximately one fourth of patients; 
      therefore advanced cardio-pulmonary investigation should be routinely performed 
      in the SSc patients' management.
CI  - Copyright (c) 2014 Australian and New Zealand Society of Cardiac and Thoracic 
      Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). 
      Published by Elsevier B.V. All rights reserved.
FAU - Demir, Nalan
AU  - Demir N
AD  - Ankara University School of Medicine, Department of Chest Diseases, 
      Ankara/Turkey.
FAU - Sahin, Ali
AU  - Sahin A
AD  - Department of Rheumatology, Ankara/Turkey.
FAU - Kucuksahin, Orhan
AU  - Kucuksahin O
AD  - Department of Rheumatology, Ankara/Turkey.
FAU - Kayacan, Oya
AU  - Kayacan O
AD  - Ankara University School of Medicine, Department of Chest Diseases, 
      Ankara/Turkey.
FAU - Dincer, Irem
AU  - Dincer I
AD  - Department of Cardiology, Ankara/Turkey.
FAU - Sayin, Tamer
AU  - Sayin T
AD  - Department of Cardiology, Ankara/Turkey.
FAU - Karnak, Demet
AU  - Karnak D
AD  - Ankara University School of Medicine, Department of Chest Diseases, 
      Ankara/Turkey. Electronic address: demet.karnak@medicine.ankara.edu.tr.
FAU - Turgay, Murat
AU  - Turgay M
AD  - Department of Rheumatology, Ankara/Turkey.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140214
PL  - Australia
TA  - Heart Lung Circ
JT  - Heart, lung & circulation
JID - 100963739
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/*epidemiology/etiology/pathology/physiopathology/therapy
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Scleroderma, 
      Systemic/complications/*epidemiology/pathology/physiopathology/therapy
OTO - NOTNLM
OT  - Diffuse cutaneous scleroderma
OT  - Interstitial lung disease
OT  - Limited cutaneous scleroderma
OT  - Pulmonary arterial hypertension
OT  - Systemic sclerosis
EDAT- 2014/03/13 06:00
MHDA- 2015/02/13 06:00
CRDT- 2014/03/12 06:00
PHST- 2013/08/27 00:00 [received]
PHST- 2014/01/25 00:00 [revised]
PHST- 2014/02/01 00:00 [accepted]
PHST- 2014/03/12 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2015/02/13 06:00 [medline]
AID - S1443-9506(14)00070-5 [pii]
AID - 10.1016/j.hlc.2014.02.002 [doi]
PST - ppublish
SO  - Heart Lung Circ. 2014 Jul;23(7):667-73. doi: 10.1016/j.hlc.2014.02.002. Epub 2014 
      Feb 14.