PMID- 24613802
OWN - NLM
STAT- MEDLINE
DCOM- 20150107
LR  - 20220409
IS  - 1873-6971 (Electronic)
IS  - 0367-326X (Linking)
VI  - 95
DP  - 2014 Jun
TI  - Effects of compound K on hyperglycemia and insulin resistance in rats with type 2 
      diabetes mellitus.
PG  - 58-64
LID - S0367-326X(14)00062-8 [pii]
LID - 10.1016/j.fitote.2014.02.017 [doi]
AB  - Compound K (CK) is a final metabolite of panaxadiol ginsenosides from Panax 
      ginseng. Although anti-diabetic activity of CK has been reported in recent years, 
      the molecular mechanism of CK in the treatment of diabetes mellitus remains 
      unclear. In the present investigation, we established a rat model of type 2 
      diabetes mellitus (T2DM) with insulin resistance using high-fat diet (HFD) and 
      streptozotocin (STZ), and attempted to verify more details and exact mechanisms 
      in the treatment of T2DM. CK was administered orally at three doses [300, 100 and 
      30 mg/kg bodyweight (b.w.)] to the diabetic rats. Bodyweight, food-intake, 
      fasting blood glucose (FBG), fasting serum insulin (FINS), insulin sensitivity 
      (ISI), total glycerin (TG), total cholesterol (TC), as well as oral glucose 
      tolerance test (OGTT) were evaluated in normal and diabetic rats. According to 
      our results, CK could improve bodyweight and food-intake of diabetic rats. CK 
      exhibited dose-dependent reduction of FBG, TG and TC of diabetic rats. CK 
      treatment also enhanced FINS and ISI. Meanwhile, the glucose tolerance observed 
      in the present study was improved significantly by CK. It is concluded from the 
      results that CK may have improving effects on hyperglycemia and insulin 
      resistance of diabetic rats. Furthermore, research showed that CK could promote 
      the expression of InsR, IRS1, PI3Kp85, pAkt and Glut4 in skeletal muscle tissue 
      of diabetic rats. These results indicate that the hypoglycemic activity of CK is 
      mediated by improvement of insulin sensitivity, which is closely related to 
      PI3K/Akt signaling pathway.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Jiang, Shuang
AU  - Jiang S
AD  - College of Pharmacy, Beihua University, Jilin, Jilin 132013, PR China; College of 
      Basic Medical Sciences, Changchun University of Chinese Medicine, Changchun, 
      Jilin 130117, PR China. Electronic address: jiangshuang_2000@163.com.
FAU - Ren, Dayong
AU  - Ren D
AD  - College of Food Science and Engineering, Jilin Agricultural University, 
      Changchun, Jilin 130117, PR China.
FAU - Li, Jianrui
AU  - Li J
AD  - Department of Personnel, Changchun University of Chinese Medicine, Changchun, 
      Jilin 130117, PR China.
FAU - Yuan, Guangxin
AU  - Yuan G
AD  - College of Pharmacy, Beihua University, Jilin, Jilin 132013, PR China; Biological 
      Macromolecular Function Development and Application of Engineering Laboratory, 
      Jilin, Jilin 132013, PR China.
FAU - Li, Hongyu
AU  - Li H
AD  - College of Pharmacy, Beihua University, Jilin, Jilin 132013, PR China; Biological 
      Macromolecular Function Development and Application of Engineering Laboratory, 
      Jilin, Jilin 132013, PR China.
FAU - Xu, Guangyu
AU  - Xu G
AD  - College of Pharmacy, Beihua University, Jilin, Jilin 132013, PR China.
FAU - Han, Xiao
AU  - Han X
AD  - College of Pharmacy, Beihua University, Jilin, Jilin 132013, PR China.
FAU - Du, Peige
AU  - Du P
AD  - College of Pharmacy, Beihua University, Jilin, Jilin 132013, PR China.
FAU - An, Liping
AU  - An L
AD  - College of Pharmacy, Beihua University, Jilin, Jilin 132013, PR China. Electronic 
      address: alp960@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140305
PL  - Netherlands
TA  - Fitoterapia
JT  - Fitoterapia
JID - 16930290R
RN  - 0 (Blood Glucose)
RN  - 0 (Ginsenosides)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 19666-76-3 (panaxadiol)
RN  - 5W494URQ81 (Streptozocin)
RN  - A9RLM212CY (ginsenoside M1)
SB  - IM
MH  - Animals
MH  - Blood Glucose/drug effects
MH  - Body Weight/drug effects
MH  - Diabetes Mellitus, Experimental/chemically induced/*drug therapy
MH  - Diabetes Mellitus, Type 2/chemically induced/*drug therapy
MH  - Diet, High-Fat
MH  - Ginsenosides/*therapeutic use
MH  - Hyperglycemia/*drug therapy
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Lipids/blood
MH  - Male
MH  - Molecular Structure
MH  - Panax/*chemistry
MH  - Plant Roots/chemistry
MH  - Rats
MH  - Rats, Wistar
MH  - Signal Transduction/drug effects
MH  - Streptozocin
OTO - NOTNLM
OT  - Compound K
OT  - Hyperglycemia
OT  - Insulin resistance
EDAT- 2014/03/13 06:00
MHDA- 2015/01/08 06:00
CRDT- 2014/03/12 06:00
PHST- 2014/01/10 00:00 [received]
PHST- 2014/02/24 00:00 [revised]
PHST- 2014/02/25 00:00 [accepted]
PHST- 2014/03/12 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2015/01/08 06:00 [medline]
AID - S0367-326X(14)00062-8 [pii]
AID - 10.1016/j.fitote.2014.02.017 [doi]
PST - ppublish
SO  - Fitoterapia. 2014 Jun;95:58-64. doi: 10.1016/j.fitote.2014.02.017. Epub 2014 Mar 
      5.