PMID- 24613855
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20190831
IS  - 1878-3252 (Electronic)
IS  - 0946-672X (Linking)
VI  - 28
IP  - 2
DP  - 2014 Apr
TI  - Efficacy of some antioxidants supplementation in reducing oxidative stress post 
      sodium tungstate exposure in male wistar rats.
PG  - 233-239
LID - S0946-672X(14)00007-8 [pii]
LID - 10.1016/j.jtemb.2014.01.004 [doi]
AB  - This study aimed to evaluate the protective efficacy of some antioxidants against 
      sodium tungstate induced oxidative stress in male wistar rats. Animals were 
      sub-chronically exposed to sodium tungstate (100ppm in drinking water) for three 
      months except for control group. In the same time, many rats were supplemented 
      orally with different antioxidants (alpha-lipoic acid (ALA), n-acetylcysteine 
      (NAC), quercetin or naringenin (0.30mM)) for five consecutive days a week for the 
      same mentioned period before. Exposure to sodium tungstate significantly (P<0.05) 
      inhibit blood delta-aminolevulinic acid dehydratase (ALAD) activity, liver and blood 
      reduced glutathione (GSH) levels and an increase in oxidized glutathione (GSSG) 
      and thiobarbituric acid reactive species (TBARS) levels in tissues. ALA acid and 
      NAC supplementation post sodium tungstate exposure increased GSH and also, was 
      beneficial in the recovery of altered superoxide dismutase and catalase activity, 
      besides, significantly reducing blood and tissue reactive oxygen species and 
      TBARS levels. The results suggest a more pronounced efficacy of ALA acid and NAC 
      supplementation than quercetin or naringenin supplementation post sodium 
      tungstate exposure in preventing induced oxidative stress in rats.
CI  - Copyright (c) 2014 Elsevier GmbH. All rights reserved.
FAU - Sachdeva, S
AU  - Sachdeva S
AD  - Division of Regulatory Toxicology, Defence Research and Development 
      Establishment, Jhansi Road, Gwalior 474 002, India.
FAU - Flora, S J S
AU  - Flora SJS
AD  - Division of Regulatory Toxicology, Defence Research and Development 
      Establishment, Jhansi Road, Gwalior 474 002, India. Electronic address: 
      sjsflora@drde.drdo.in.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140209
PL  - Germany
TA  - J Trace Elem Med Biol
JT  - Journal of trace elements in medicine and biology : organ of the Society for 
      Minerals and Trace Elements (GMS)
JID - 9508274
RN  - 0 (Antioxidants)
RN  - 0 (Tungsten Compounds)
RN  - 64LRH4405G (sodium tungstate(VI))
RN  - EC 4.2.1.24 (Porphobilinogen Synthase)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Body Weight/drug effects
MH  - *Dietary Supplements
MH  - Liver/drug effects/pathology
MH  - Male
MH  - Oxidative Stress/*drug effects
MH  - Porphobilinogen Synthase/blood
MH  - Rats, Wistar
MH  - Spleen/drug effects/pathology
MH  - Tungsten Compounds/*toxicity
OTO - NOTNLM
OT  - Antioxidant
OT  - Flavonoids
OT  - Oxidative stress
OT  - Rats
OT  - Sodium tungstate toxicity
EDAT- 2014/03/13 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/03/12 06:00
PHST- 2013/11/13 00:00 [received]
PHST- 2014/01/06 00:00 [revised]
PHST- 2014/01/28 00:00 [accepted]
PHST- 2014/03/12 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0946-672X(14)00007-8 [pii]
AID - 10.1016/j.jtemb.2014.01.004 [doi]
PST - ppublish
SO  - J Trace Elem Med Biol. 2014 Apr;28(2):233-239. doi: 10.1016/j.jtemb.2014.01.004. 
      Epub 2014 Feb 9.