PMID- 24615932 OWN - NLM STAT- MEDLINE DCOM- 20150306 LR - 20211021 IS - 1097-0193 (Electronic) IS - 1065-9471 (Print) IS - 1065-9471 (Linking) VI - 35 IP - 9 DP - 2014 Sep TI - Emotional fronto-cingulate cortex activation and brain derived neurotrophic factor polymorphism in premenstrual dysphoric disorder. PG - 4450-8 LID - 10.1002/hbm.22486 [doi] AB - Premenstrual dysphoric disorder (PMDD) is the prototypical sex-specific disorder in which symptom onset and offset require a particular hormonal milieu and for which there is moderate heritability. The present study investigated brain emotion processing in PMDD and healthy controls, as well as functional polymorphisms in two candidate genes for PMDD, the serotonin transporter (5-HTT) and brain derived neurotrophic factor (BDNF). The 5-HTT linked polymorphic region (5-HTTLPR) and BDNF Val66Met polymorphisms were genotyped in 31 patients with PMDD and 31 healthy controls. A subset of 16 patients and 15 controls participated in two functional magnetic resonance imaging-sessions performing an emotion processing task; once in the mid-follicular, and once in the late luteal phase which corresponds with maximum severity of mood symptoms. Genotypes were not directly associated with PMDD. A main effect of group was found in the whole brain analysis, with patients having lower activation of the pre-genual anterior cingulate and ventro-medial prefrontal cortex, independent of menstrual cycle phase. Post-hoc functional ROI analyses in the fronto-cingulate cluster showed no effect of 5-HTTLPR genotype but a genotype-by-group-by-phase interaction effect of BDNF Val66Met. Women with PMDD who were carriers of the Met-allele had lower fronto-cingulate cortex activation in the luteal phase compared to Met-allele carrying controls. The results provide suggestive evidence of impaired emotion-induced fronto-cingulate cortex activation in PMDD patients. Although limited by a small sample, the potential influence of BDNF Val66Met in PMDD is in line with preclinical findings. CI - Copyright (c) 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc. FAU - Comasco, Erika AU - Comasco E AD - Department of Neuroscience, Uppsala University, Uppsala, Sweden. FAU - Hahn, Andreas AU - Hahn A FAU - Ganger, Sebastian AU - Ganger S FAU - Gingnell, Malin AU - Gingnell M FAU - Bannbers, Elin AU - Bannbers E FAU - Oreland, Lars AU - Oreland L FAU - Wikstrom, Johan AU - Wikstrom J FAU - Epperson, C Neill AU - Epperson CN FAU - Lanzenberger, Rupert AU - Lanzenberger R FAU - Sundstrom-Poromaa, Inger AU - Sundstrom-Poromaa I LA - eng GR - K24 DA030301/DA/NIDA NIH HHS/United States GR - P50 MH099910/MH/NIMH NIH HHS/United States GR - K24 DA03031/DA/NIDA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20140225 PL - United States TA - Hum Brain Mapp JT - Human brain mapping JID - 9419065 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (SLC6A4 protein, human) RN - 0 (Serotonin Plasma Membrane Transport Proteins) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Brain/physiopathology MH - Brain Mapping MH - Brain-Derived Neurotrophic Factor/*genetics MH - Emotions/*physiology MH - Female MH - Follicular Phase/physiology MH - Frontal Lobe/*physiopathology MH - Genotype MH - Genotyping Techniques MH - Gyrus Cinguli/*physiopathology MH - Humans MH - Luteal Phase/physiology MH - Magnetic Resonance Imaging MH - *Polymorphism, Single Nucleotide MH - Premenstrual Dysphoric Disorder/*physiopathology/psychology MH - Serotonin Plasma Membrane Transport Proteins/genetics MH - Signal Processing, Computer-Assisted PMC - PMC4107029 MID - NIHMS562685 OTO - NOTNLM OT - 5-HTTLPR OT - BDNF Val66Met OT - anterior cingulate cortex OT - emotion OT - fMRI OT - premenstrual dysphoric disorder EDAT- 2014/03/13 06:00 MHDA- 2015/03/07 06:00 PMCR- 2014/02/25 CRDT- 2014/03/12 06:00 PHST- 2013/11/07 00:00 [received] PHST- 2014/01/22 00:00 [revised] PHST- 2014/01/30 00:00 [accepted] PHST- 2014/03/12 06:00 [entrez] PHST- 2014/03/13 06:00 [pubmed] PHST- 2015/03/07 06:00 [medline] PHST- 2014/02/25 00:00 [pmc-release] AID - HBM22486 [pii] AID - 10.1002/hbm.22486 [doi] PST - ppublish SO - Hum Brain Mapp. 2014 Sep;35(9):4450-8. doi: 10.1002/hbm.22486. Epub 2014 Feb 25.