PMID- 24616129
OWN - NLM
STAT- MEDLINE
DCOM- 20150914
LR  - 20211021
IS  - 1521-3773 (Electronic)
IS  - 1433-7851 (Print)
IS  - 1433-7851 (Linking)
VI  - 53
IP  - 15
DP  - 2014 Apr 7
TI  - The potent oxidant anticancer activity of organoiridium catalysts.
PG  - 3941-6
LID - 10.1002/anie.201311161 [doi]
AB  - Platinum complexes are the most widely used anticancer drugs; however, new 
      generations of agents are needed. The organoiridium(III) complex [(eta(5) 
      -Cp(xbiph) )Ir(phpy)(Cl)] (1-Cl), which contains pi-bonded 
      biphenyltetramethylcyclopentadienyl (Cp(xbiph) ) and C;N-chelated phenylpyridine 
      (phpy) ligands, undergoes rapid hydrolysis of the chlorido ligand. In contrast, 
      the pyridine complex [(eta(5) -Cp(xbiph) )Ir(phpy)(py)](+) (1-py) aquates slowly, 
      and is more potent (in nanomolar amounts) than both 1-Cl and cisplatin towards a 
      wide range of cancer cells. The pyridine ligand protects 1-py from rapid reaction 
      with intracellular glutathione. The high potency of 1-py correlates with its 
      ability to increase substantially the level of reactive oxygen species (ROS) in 
      cancer cells. The unprecedented ability of these iridium complexes to generate H2 
      O2 by catalytic hydride transfer from the coenzyme NADH to oxygen is 
      demonstrated. Such organoiridium complexes are promising as a new generation of 
      anticancer drugs for effective oxidant therapy.
CI  - (c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Liu, Zhe
AU  - Liu Z
AD  - Department of Chemistry, University of Warwick, Coventry, CV4 7AL (UK).
FAU - Romero-Canelon, Isolda
AU  - Romero-Canelon I
FAU - Qamar, Bushra
AU  - Qamar B
FAU - Hearn, Jessica M
AU  - Hearn JM
FAU - Habtemariam, Abraha
AU  - Habtemariam A
FAU - Barry, Nicolas P E
AU  - Barry NP
FAU - Pizarro, Ana M
AU  - Pizarro AM
FAU - Clarkson, Guy J
AU  - Clarkson GJ
FAU - Sadler, Peter J
AU  - Sadler PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140311
PL  - Germany
TA  - Angew Chem Int Ed Engl
JT  - Angewandte Chemie (International ed. in English)
JID - 0370543
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Reactive Oxygen Species)
RN  - 44448S9773 (Iridium)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Antineoplastic Agents/*chemistry
MH  - Catalysis
MH  - Cisplatin/*chemistry
MH  - Humans
MH  - Iridium/*chemistry
MH  - Models, Molecular
MH  - Organometallic Compounds/*chemistry
MH  - Reactive Oxygen Species
MH  - Structure-Activity Relationship
PMC - PMC4227564
OTO - NOTNLM
OT  - anticancer drugs
OT  - biocatalysts
OT  - hydride transfer
OT  - iridium
OT  - reactive oxygen species
EDAT- 2014/03/13 06:00
MHDA- 2015/09/15 06:00
PMCR- 2014/11/11
CRDT- 2014/03/12 06:00
PHST- 2013/12/23 00:00 [received]
PHST- 2014/03/12 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2015/09/15 06:00 [medline]
PHST- 2014/11/11 00:00 [pmc-release]
AID - 10.1002/anie.201311161 [doi]
PST - ppublish
SO  - Angew Chem Int Ed Engl. 2014 Apr 7;53(15):3941-6. doi: 10.1002/anie.201311161. 
      Epub 2014 Mar 11.