PMID- 24616993
OWN - NLM
STAT- MEDLINE
DCOM- 20150516
LR  - 20181202
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 27
IP  - 21
DP  - 2013 Nov
TI  - [Synovial sarcoma of the head and neck--a retrospective study of 39 cases].
PG  - 1167-70
AB  - OBJECTIVE: Synovial sarcoma (SS) of the head and neck is rare in comparison with 
      those took place in the extremities. This study was planned to investigate the 
      relationship between pathological diagnosis, tumor location and clinical outcome 
      of SS of the head and neck. METHOD: Thirty-nine cases of SS in head and neck 
      hospitalized in West China Hospital from 1966 to 2011 was retrospectively studied 
      by reviewing the medical record data, the pathological slices of the operative 
      specimen and followed-up from 1 to 192 months with the mean time of 43.2 months 
      postoperatively. The parameters of clinical outcome were focused on the time to 
      first recurrence after primary surgery and follow-up time. The reviewed results 
      were statistically processed. RESULT: The age of the patients ranged from 8 to 66 
      years old with the median age of 35, among them 27 are males. Pathologically, 18 
      cases are biphasic, 17 cases are monophasic and 3 cases are low-differentiated 
      SS. 4 cases were proved by cytogenetic methods of either fluorescence in situ 
      hybridization(FISH) or RT-PCR. 23 cases experienced repeated recurrence with the 
      most up to 4 times operations after sole surgical approach. Only one lymphatic 
      metastasis was suspected in all. 16 patients got adjuvant radiotherapy or 
      chemotherapy. 4 patients died but only one death was associated directly with SS 
      recurrence. There was no significant relationship between pathological subtype 
      and recurrence (Fisher's Exact Test P-value > 0.05), no significant relationship 
      between tumor location and recurrence (Fisher's Exact Test P-value > 0.05). 
      CONCLUSION: SS of head and neck is a special entity that has potential of easy 
      recurrence but good prognosis. Surgery should still be the primary treatment 
      approach. Cytogenetic methods are recommended to as certain the diagnosis in 
      order to choose reasonable treatment protocols.
FAU - Li, Wen
AU  - Li W
FAU - Yang, Liu
AU  - Yang L
FAU - Li, Qiong
AU  - Li Q
FAU - Chen, Min
AU  - Chen M
FAU - Zhang, Hongying
AU  - Zhang H
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - China
MH  - Female
MH  - Head and Neck Neoplasms/genetics/*pathology/therapy
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - *Neoplasm Recurrence, Local
MH  - Retrospective Studies
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sarcoma, Synovial/genetics/*pathology/therapy
MH  - Young Adult
EDAT- 2014/03/13 06:00
MHDA- 2015/05/20 06:00
CRDT- 2014/03/13 06:00
PHST- 2014/03/13 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Nov;27(21):1167-70.