PMID- 24616997
OWN - NLM
STAT- MEDLINE
DCOM- 20150516
LR  - 20211203
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 27
IP  - 21
DP  - 2013 Nov
TI  - [The expression of BUB1 in laryngeal squamous cell carcinoma and its clinical 
      significance].
PG  - 1184-7
AB  - OBJECTIVE: To investigate the expression and clinical significance of BUB1 
      protein in laryngeal squa mous cell carcinoma (LSCC) tissues. METHOD: The 
      expression of BUB1 protein was measured by immunohistochemistry (EliVision two 
      steps) in 55 cases of LSCC tissues,30 cases of adjacent normal laryngeal mucosa 
      tissues, the relationship of BUB1 expression with clinical pathologic factors in 
      LSCC was also analyzed. RESULT: The positive rate of BUB1 protein in LSCC tissues 
      (50.9%, 28/55) was significantly lower than that in adjacent normal laryngeal 
      mucosa tissues (83.3%, 25/30), P < 0.01. The positive rate of BUB1 protein was 
      correlated with differentiation grading and lymph node metastasis of LSCC (P < 
      0.05, respectively), but not with patient's sex, age, smoking, tumor site, 
      T-stage and clinical stage(P > 0.05, respectively). CONCLUSION: The low 
      expresssion of BUB1 protein is closely related to the tumorigenesis and 
      development of LSCC, and can be a molecular marker for prognosticating metastasis 
      and prognosis of LSCC.
FAU - Li, Zhaolong
AU  - Li Z
FAU - Chen, Yingchao
AU  - Chen Y
FAU - Yan, Fubo
AU  - Yan F
FAU - Zhang, Qingyuan
AU  - Zhang Q
FAU - Zhou, Jie
AU  - Zhou J
FAU - Yang, Jizhou
AU  - Yang J
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Neoplasm Proteins)
RN  - EC 2.7.11.1 (BUB1 protein, human)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Mucosa/metabolism
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*metabolism
MH  - Prognosis
MH  - Protein Serine-Threonine Kinases/*metabolism
EDAT- 2014/03/13 06:00
MHDA- 2015/05/20 06:00
CRDT- 2014/03/13 06:00
PHST- 2014/03/13 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Nov;27(21):1184-7.