PMID- 24617542
OWN - NLM
STAT- MEDLINE
DCOM- 20140430
LR  - 20140312
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 77
IP  - 7
DP  - 2014
TI  - Perinatal androgenic exposure and reproductive health effects female rat 
      offspring.
PG  - 375-89
LID - 10.1080/15287394.2013.874881 [doi]
AB  - Environmental contaminants known as endocrine-disrupting chemicals (EDC) have 
      been associated with adverse effects on reproductive processes. These chemicals 
      may mimic or antagonize endogenous hormones, disrupting reproductive functions. 
      Although preliminary studies focused on environmental estrogens, the presence of 
      compounds with androgenic activity has also been described. This study examines 
      exposure of female pregnant and lactating rats to low doses of androgens and 
      assesses potential effects on female offspring. Pregnant Wistar rats were exposed 
      to testosterone propionate (TP) at doses of 0.05, 0.1, or 0.2 mg/kg or corn oil 
      (vehicle), subcutaneously, to determine influence on reproductive health of 
      female offspring. There were two exposure groups: (1) rats treated from 
      gestational day (GD) 12 until GD 20; and (2) animals treated from GD 12 until the 
      end of lactation. Perinatal exposure to TP produced increased anogenital distance 
      after birth and diminished height of uterine glandular epithelium at puberty in 
      animals exposed to 0.2 mg/kg. However, these alterations were not sufficient to 
      impair sexual differentiation and normal physiology of the female rat 
      reproductive tract.
FAU - Guerra, Marina T
AU  - Guerra MT
AD  - a Graduate Program in Cell and Structural Biology , Institute of Biology, State 
      University of Campinas-UNICAMP , Campinas , Sao Paulo , Brazil.
FAU - Silva, Raquel F
AU  - Silva RF
FAU - Luchiari, Heloise R
AU  - Luchiari HR
FAU - Sanabria, Marciana
AU  - Sanabria M
FAU - Kempinas, Wilma De Grava
AU  - Kempinas Wde G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 0 (Androgens)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Teratogens)
RN  - WI93Z9138A (Testosterone Propionate)
SB  - IM
MH  - Androgens/administration & dosage/*toxicity
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Endocrine Disruptors/administration & dosage/*toxicity
MH  - Endometrium/abnormalities/drug effects
MH  - Environmental Pollutants/administration & dosage/*toxicity
MH  - Female
MH  - Fetal Development/drug effects
MH  - Injections, Subcutaneous
MH  - *Lactation
MH  - Maternal Exposure/adverse effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Sexual Development/*drug effects
MH  - Teratogens/toxicity
MH  - Testosterone Propionate/administration & dosage/toxicity
MH  - Urogenital Abnormalities/*chemically induced
EDAT- 2014/03/13 06:00
MHDA- 2014/05/03 06:00
CRDT- 2014/03/13 06:00
PHST- 2014/03/13 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
AID - 10.1080/15287394.2013.874881 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 2014;77(7):375-89. doi: 10.1080/15287394.2013.874881.