PMID- 24618287
OWN - NLM
STAT- MEDLINE
DCOM- 20150113
LR  - 20140326
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 17
IP  - 3
DP  - 2014 Mar
TI  - HLA-DR typing in polyarticular juvenile idiopathic arthritis: a study from a 
      tertiary care hospital in northern India.
PG  - 268-73
LID - 10.1111/1756-185X.12198 [doi]
AB  - INTRODUCTION: Many studies of human leukocyte antigen (HLA) association with 
      juvenile idiopathic arthritis (JIA) have reported conflicting results, which were 
      probably related to ethnic differences. Moreover, in India, studies on HLA-DR 
      typing on JIA, particularly polyarticular JIA, is lacking. OBJECTIVE: The aim of 
      our study was to reveal the frequency of HLA DR types in a cohort of 
      polyarticular JIA in northern India. METHODS: Fifty-two polyarticular JIA 
      patients were included as per the recent International League of Associations for 
      Rheumatology classification, 2001. HLA-DR typing was performed in 21 patients (18 
      rheumatoid factor [RF]+ and three RF-) by a DNA-based polymerase chain reaction 
      method for the determination of HLA alleles using sequence specific primers 
      (SSP). The results were compared with that of 23 healthy controls of the same age 
      and sex. RESULTS: HLA-DR4 was present in five cases (23%) in the diseased group 
      while only in one case (4.3%) in the control group with a relative risk of 5.47, 
      but when compared with only RF+ polyarticular JIA, HLA-DR4 was found to be 
      significantly high (27.7% vs. 4.43%; P < 0.05) with a relative risk of 6.3. 
      Further, DR4, DR1, DR2, DR9, DR10 were also non-significantly high in these 
      patients with relative risk of 3.2 for DR9 and 1.8 for DR10. In contrast, HLA-DR6 
      was seen only in 5.5% of polyarticular JIA cases, whereas it was present in 39% 
      of controls (P < 0.05), a showing negative association. CONCLUSION: HLA-DR4 codes 
      for susceptibility to RF+ polyarticular JIA with a six-fold risk, whereas HLA-DR6 
      offers protection.
CI  - (c) 2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing 
      Asia Pty Ltd.
FAU - Dibya Ranjan, Behera
AU  - Dibya Ranjan B
AD  - Department of Medicine, Banaras Hindu University, Varanasi, India.
FAU - Nand Kumar, Singh
AU  - Nand Kumar S
FAU - Usha, Singh
AU  - Usha S
FAU - Pramod Kumar, Verma
AU  - Pramod Kumar V
LA  - eng
PT  - Journal Article
DEP - 20131101
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR4 Antigen)
RN  - 0 (HLA-DR6 Antigen)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Adolescent
MH  - Arthritis, Juvenile/*ethnology/*genetics/metabolism
MH  - Case-Control Studies
MH  - Child
MH  - Cohort Studies
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - *Genotype
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DR4 Antigen/*genetics
MH  - HLA-DR6 Antigen/genetics
MH  - Humans
MH  - India
MH  - Male
MH  - Rheumatoid Factor/metabolism
MH  - Risk Factors
MH  - Tertiary Care Centers
OTO - NOTNLM
OT  - HLA-DR
OT  - juvenile idiopathic arthritis
OT  - polyarticular JIA
EDAT- 2014/03/13 06:00
MHDA- 2015/01/15 06:00
CRDT- 2014/03/13 06:00
PHST- 2014/03/13 06:00 [entrez]
PHST- 2014/03/13 06:00 [pubmed]
PHST- 2015/01/15 06:00 [medline]
AID - 10.1111/1756-185X.12198 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2014 Mar;17(3):268-73. doi: 10.1111/1756-185X.12198. Epub 2013 
      Nov 1.